Frozen-thawed embryo transfer: does the addition of low-dose choriogonadotropin alfa to progesterone in the luteal phase of artificial cycles improve the endometrium and increase the chances of pregnancy?

IF 1.8 Q3 OBSTETRICS & GYNECOLOGY Jornal Brasileiro de Reproducao Assistida Pub Date : 2024-02-26 DOI:10.5935/1518-0557.20230053
Rodopiano de Souza Florêncio, Mylena Naves de Castro Rocha, Vinicius Alves de Oliveira, Marta Curado Carvalho Franco Finotti
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Abstract

Objective: Primary: To evaluate the effect of low doses of recombinant hCG (choriogonadotropin alfa) in the luteal phase of frozen-thawed embryo transfers (FET) of artificial cycles on the chances of pregnancy in patients aged ≤38years. Secondary: To assess the chances of pregnancy in the FET groups of artificial cycles using micronized vaginal progesterone (VP) versus injectable intramuscular progesterone (IMP) and the chances of pregnancy in type-1 embryo transfers (two top embryos).

Methods: This retrospective cohort study included 122 cycles of FET and compared two groups of patients aged 38 years or younger, one given hCG in the luteal phase and one not administered hCG.

Results: The clinical pregnancy rates (CPR) in the control and hCG groups were 45% and 45.16%, respectively (p=0.9999). The live birth rates (LBR) were 33.33% and 32.25%, respectively, (p=0.99909). The CPR in the VP group (83 patients) was 46.89% versus 41.02% in the IMP group, (p=0.5459). The LBR was 33.73% in the VP group and 30.76% in the IMP group (39 patients), (p=0.7559).

Conclusions: The CPR and LBR of patients undergoing FET in groups prescribed and not prescribed low doses of recombinant hCG were similar. No significant difference was found between patients given VP or IMP.

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冻融胚胎移植:在人工周期的黄体期添加低剂量绒毛膜促性腺激素是否能改善子宫内膜并增加怀孕机会?
目的:初步探讨人工周期冻融胚胎移植(FET)黄体期低剂量重组绒毛膜促性腺激素(hCG)对年龄≤38岁患者妊娠几率的影响。次要:评估使用微阴道孕酮(VP)与注射肌内孕酮(IMP)人工周期FET组的妊娠机会,以及1型胚胎移植(两个顶部胚胎)的妊娠机会。方法:这项回顾性队列研究包括122个周期的FET,并比较两组年龄在38岁或以下的患者,一组在黄体期给予hCG,一组未给予hCG。结果:对照组和hCG组临床妊娠率(CPR)分别为45%和45.16% (p=0.9999)。活产率(LBR)分别为33.33%和32.25%,差异有统计学意义(p=0.99909)。VP组(83例)心肺复苏率为46.89%,IMP组为41.02%,差异有统计学意义(p=0.5459)。VP组LBR为33.73%,IMP组为30.76%(39例),p=0.7559。结论:低剂量重组hCG组和非低剂量重组hCG组FET患者的CPR和LBR相似。注射VP或IMP的患者间无显著差异。
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来源期刊
CiteScore
3.30
自引率
6.70%
发文量
56
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