{"title":"The AAPS Journal Theme Issue: \"Perspectives on Clinical Drug Development of Long-Acting Injectables\".","authors":"Huybrecht T'jollyn, Oliver Ackaert","doi":"10.1208/s12248-023-00871-w","DOIUrl":null,"url":null,"abstract":"The development of long-acting injectable (LAI) drugs has gained increased interest during the last decades because of their favorable properties towards compliance, safety, and efficacy by maintaining stable drug concentrations throughout an extended period following a single intramuscular (IM) or subcutaneous (SC) injection. Historically, several LAIs have been successfully marketed, mainly as lifecycle product extensions of oral formulations (1). More recently, several therapeutics are also being developed for LAI use only with limited or no information available from oral administration to be leveraged (2). There is therefore a need for more quantitative understanding of (i) the physicochemical properties, (ii) the influence of the formulations","PeriodicalId":50934,"journal":{"name":"AAPS Journal","volume":null,"pages":null},"PeriodicalIF":5.0000,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"AAPS Journal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1208/s12248-023-00871-w","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0
Abstract
The development of long-acting injectable (LAI) drugs has gained increased interest during the last decades because of their favorable properties towards compliance, safety, and efficacy by maintaining stable drug concentrations throughout an extended period following a single intramuscular (IM) or subcutaneous (SC) injection. Historically, several LAIs have been successfully marketed, mainly as lifecycle product extensions of oral formulations (1). More recently, several therapeutics are also being developed for LAI use only with limited or no information available from oral administration to be leveraged (2). There is therefore a need for more quantitative understanding of (i) the physicochemical properties, (ii) the influence of the formulations
期刊介绍：
The AAPS Journal, an official journal of the American Association of Pharmaceutical Scientists (AAPS), publishes novel and significant findings in the various areas of pharmaceutical sciences impacting human and veterinary therapeutics, including:
· Drug Design and Discovery
· Pharmaceutical Biotechnology
· Biopharmaceutics, Formulation, and Drug Delivery
· Metabolism and Transport
· Pharmacokinetics, Pharmacodynamics, and Pharmacometrics
· Translational Research
· Clinical Evaluations and Therapeutic Outcomes
· Regulatory Science
We invite submissions under the following article types:
· Original Research Articles
· Reviews and Mini-reviews
· White Papers, Commentaries, and Editorials
· Meeting Reports
· Brief/Technical Reports and Rapid Communications
· Regulatory Notes
· Tutorials
· Protocols in the Pharmaceutical Sciences
In addition, The AAPS Journal publishes themes, organized by guest editors, which are focused on particular areas of current interest to our field.
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