Importance of Metal Biotransformation in Cell Response to Metallic Nanoparticles: A Transcriptomic Meta-analysis Study

IF 4.8 Q2 NANOSCIENCE & NANOTECHNOLOGY ACS Nanoscience Au Pub Date : 2022-09-30 DOI:10.1021/acsnanoscienceau.2c00035
Alice Balfourier, Anne-Pia Marty and Florence Gazeau*, 
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引用次数: 3

Abstract

Metallic nanoparticles are increasingly present in our environment, raising concerns on their interactions with living organisms and potential toxicity. Indeed, metallic nanoparticles release metal ions that can be toxic, bioessential, therapeutically active, or combine several of these features. However, human cell responses to different metallic nanoparticles and ions have rarely been compared so far. We propose here a meta-analysis of the transcriptomic responses of human cells to nanoparticles and ions of various metals (titanium, iron, copper, zinc, silver, cadmium, platinum, gold), in order to identify the commonalities and differences between cell responses to these compounds. This analysis revealed that the chemical properties of metals are more important than their known biological functions (i.e., essential metals, toxicity) in governing the cell transcriptome. Particularly, we evidence that the response to nanoparticles is dominated by the response to the ions they contain, and depend on the nanoparticles’ solubility. The formulation as nanoparticles impacts the cell response at lower intensity than the released ions, by altering genes related to vesicle intracellular transport and the cytoskeleton. Moreover, we put into light that several metals (i.e., copper, zinc, silver, cadmium, and gold) trigger a common cell response governed by metallothioneins, which coexist with singular signatures that are specific to a given element.

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金属生物转化在细胞对金属纳米颗粒反应中的重要性:一项转录组meta分析研究
金属纳米颗粒越来越多地存在于我们的环境中,这引发了人们对其与生物体相互作用和潜在毒性的担忧。事实上,金属纳米颗粒释放的金属离子可以是有毒的、生物本质的、治疗活性的,或者结合了其中的几个特征。然而,到目前为止,人类细胞对不同金属纳米颗粒和离子的反应很少进行比较。我们在此提出了一项关于人类细胞对各种金属(钛、铁、铜、锌、银、镉、铂、金)的纳米颗粒和离子的转录组反应的荟萃分析,以确定细胞对这些化合物的反应之间的共性和差异。该分析表明,在控制细胞转录组方面,金属的化学性质比其已知的生物功能(即必需金属、毒性)更重要。特别是,我们证明,对纳米颗粒的反应主要由对其所含离子的反应决定,并取决于纳米颗粒的溶解度。作为纳米颗粒的制剂通过改变与囊泡细胞内运输和细胞骨架相关的基因,以比释放的离子更低的强度影响细胞反应。此外,我们发现几种金属(即铜、锌、银、镉和金)会触发由金属硫蛋白控制的常见细胞反应,金属硫蛋白与特定元素特有的奇异特征共存。
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来源期刊
ACS Nanoscience Au
ACS Nanoscience Au 材料科学、纳米科学-
CiteScore
4.20
自引率
0.00%
发文量
0
期刊介绍: ACS Nanoscience Au is an open access journal that publishes original fundamental and applied research on nanoscience and nanotechnology research at the interfaces of chemistry biology medicine materials science physics and engineering.The journal publishes short letters comprehensive articles reviews and perspectives on all aspects of nanoscience and nanotechnology:synthesis assembly characterization theory modeling and simulation of nanostructures nanomaterials and nanoscale devicesdesign fabrication and applications of organic inorganic polymer hybrid and biological nanostructuresexperimental and theoretical studies of nanoscale chemical physical and biological phenomenamethods and tools for nanoscience and nanotechnologyself- and directed-assemblyzero- one- and two-dimensional materialsnanostructures and nano-engineered devices with advanced performancenanobiotechnologynanomedicine and nanotoxicologyACS Nanoscience Au also publishes original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials engineering physics bioscience and chemistry into important applications of nanomaterials.
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