Same Day Biopsy and Treatment of Non-Melanoma Skin Cancer in Patients with Field Cancerization: A Retrospective Chart Study.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2023-01-01 DOI:10.1155/2023/9990046

Jonathan Miles, Camila Luis-Gronau, Estefania Cruzval-O'Reilly, Aida Lugo-Somolinos, Puneet S Jolly

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Abstract

Background: Patients with field cancerization will develop numerous superficial non-melanoma skin cancers (NMSCs). Treating patients with field cancerization can be challenging and burdensome due to the numerous non-melanoma skin cancers (NMSCs) they develop and the frequent dermatology visits required for biopsy and treatment.

Objective: The success rate of diagnosing and treating lesions suspicious for NMSCs on the same day is measured, immediately after biopsy.

Methods: We retrospectively reviewed records of patients with same day lesion diagnosis and curettage treatment to determine diagnostic accuracy, treatment failure, and number needed to treat to reduce a follow-up treatment.

Results: A total of 237 lesions underwent same day biopsy and treatment, of which the majority were NMSC (66%) or actinic keratosis (23%). Patients had at least 3 months and a median of 17 months follow-up. A total of 20 lesions either recurred or were deemed to require additional treatment. The number needed to treat (NNT) to prevent one follow-up treatment was 1.3. Limitations: sample size limited ability to determine risk factors for treatment failure.

Conclusion: Simultaneous diagnosis and treatment of superficial NMSCs is a successful way of improving efficiency and patient satisfaction.

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非黑色素瘤皮肤癌野外癌变患者的当天活检和治疗:回顾性图表研究。

背景:野癌患者会发展为许多浅表非黑色素瘤皮肤癌(NMSCs)。野区癌变患者的治疗具有挑战性和繁重性，因为他们会发展出大量的非黑色素瘤皮肤癌(NMSCs)，并且需要频繁地去皮肤科进行活检和治疗。目的:测定活检后即刻当天诊断和治疗NMSCs可疑病变的成功率。方法:我们回顾性回顾当天病变诊断和刮痧治疗的患者记录，以确定诊断的准确性、治疗失败和需要治疗的人数，以减少随访治疗。结果:共有237个病变在同一天进行了活检和治疗，其中大多数为NMSC(66%)或光化性角化病(23%)。患者至少随访3个月，中位随访17个月。共有20个病变复发或被认为需要额外治疗。预防一次随访治疗所需治疗数(NNT)为1.3。局限性:样本量有限，无法确定治疗失败的危险因素。结论:浅表神经间充质干细胞的诊治是提高治疗效率和患者满意度的有效途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.