Gamma-Glutamyl Transferase: A Friend against Cholestatic Itch? A Retrospective Observational Data Analysis in Patients with Extrahepatic Cholestasis.

IF 1.5 Q3 GASTROENTEROLOGY & HEPATOLOGY International Journal of Hepatology Pub Date : 2023-01-01 DOI:10.1155/2023/2903171

Floris W Haijer, Cornelis B Van Vliet, Marjolein G J Brusse-Keizer, Job A M Van der Palen, Marjo J Kerbert-Dreteler, Jeroen J Kolkman

{"title":"Gamma-Glutamyl Transferase: A Friend against Cholestatic Itch? A Retrospective Observational Data Analysis in Patients with Extrahepatic Cholestasis.","authors":"Floris W Haijer, Cornelis B Van Vliet, Marjolein G J Brusse-Keizer, Job A M Van der Palen, Marjo J Kerbert-Dreteler, Jeroen J Kolkman","doi":"10.1155/2023/2903171","DOIUrl":null,"url":null,"abstract":"Methods: We included 235 patients with chronic extrahepatic cholestasis due to pancreatic cancer, cholangiocarcinoma, or papillary carcinoma.Results: GGT was significantly higher in patients without pruritus (median 967, IQR 587-1571) compared to patients with pruritus (median 561 IQR 266-1084 IU/l) (p < 0.01). In contrast, median alkaline phosphatase (AP) was 491 U/L (IQR; 353-684) in patients with pruritus and was not significantly different from 518 U/L (IQR; 353-726) in patients without pruritus (p = 0.524). Direct bilirubin was significantly higher in patients with pruritus compared to patients without pruritus (168 μmol/L (IQR; 95-256) vs. 120 μmol/L (IQR; 56.75-185.5)) (p < 0.01). After correcting for the extent of cholestasis via direct bilirubin, the negative association between GGT and pruritus remained significant and became stronger (p < 0.001).Conclusion: Serum GGT activity is inversely associated with the presence of cholestatic itch in patients with chronic extrahepatic cholestasis.","PeriodicalId":46297,"journal":{"name":"International Journal of Hepatology","volume":"2023 ","pages":"2903171"},"PeriodicalIF":1.5000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9931488/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Hepatology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1155/2023/2903171","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Methods: We included 235 patients with chronic extrahepatic cholestasis due to pancreatic cancer, cholangiocarcinoma, or papillary carcinoma.

Results: GGT was significantly higher in patients without pruritus (median 967, IQR 587-1571) compared to patients with pruritus (median 561 IQR 266-1084 IU/l) (p < 0.01). In contrast, median alkaline phosphatase (AP) was 491 U/L (IQR; 353-684) in patients with pruritus and was not significantly different from 518 U/L (IQR; 353-726) in patients without pruritus (p = 0.524). Direct bilirubin was significantly higher in patients with pruritus compared to patients without pruritus (168 μmol/L (IQR; 95-256) vs. 120 μmol/L (IQR; 56.75-185.5)) (p < 0.01). After correcting for the extent of cholestasis via direct bilirubin, the negative association between GGT and pruritus remained significant and became stronger (p < 0.001).

Conclusion: Serum GGT activity is inversely associated with the presence of cholestatic itch in patients with chronic extrahepatic cholestasis.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

-谷氨酰转移酶:对抗胆汁淤积性瘙痒的朋友?肝外胆汁淤积症患者的回顾性观察资料分析。

方法:我们纳入了235例由胰腺癌、胆管癌或乳头状癌引起的慢性肝外胆汁淤积症患者。结果:无瘙痒症患者GGT(中位数967,IQR 587-1571)明显高于瘙痒症患者(中位数561,IQR 266-1084) (p < 0.01)。碱性磷酸酶(AP)中位数为491 U/L (IQR;353-684)，与518 U/L (IQR;353-726)，无瘙痒患者(p = 0.524)。瘙痒患者直接胆红素明显高于无瘙痒患者(168 μmol/L (IQR;95 ~ 256) vs. 120 μmol/L (IQR;56.75-185.5))) (p < 0.01)。通过直接胆红素校正胆汁淤积程度后，GGT与瘙痒之间的负相关仍然显著且变得更强(p < 0.001)。结论:慢性肝外胆汁淤积症患者血清GGT活性与胆汁淤积性瘙痒呈负相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

International Journal of Hepatology GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

3.80

自引率

0.00%

发文量

审稿时长

15 weeks

期刊介绍： International Journal of Hepatology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to the medical, surgical, pathological, biochemical, and physiological aspects of hepatology, as well as the management of disorders affecting the liver, gallbladder, biliary tree, and pancreas.