The accuracy of serum osmolarity calculation in small children.

IF 2 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Journal of Medical Biochemistry Pub Date : 2023-01-20 DOI:10.5937/jomb0-37490

Joanna Berska, Jolanta Bugajska, Krystyna Sztefko

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Abstract

Background: Serum osmolality can be measured (Omeas) or calculated (Ocal). Many formulas for Ocal have been already published, but data regarding the most accurate equation in small babies is not available. Thus, we aim to compare Omeas and Ocal obtained by different formulas in newborns and small children.

Methods: The study included 280 serum samples taken from children, from the first day of life to 2 years (mean age 8.2 ± 7.6 months) treated in the University Children's Hospital in Krakow. The serum osmolality was measured by osmometer and calculated by 8 common formulas.

Results: The mean value of Omeas (2 8 5 .8 ± 5 .1 mOsm/kgH2O) was significantly different as compared to the mean values of Ocal (p< 0.01) for all formulas, except Ocal obtained by the formula: 1.86*(N a + K) +1.15*Glu + Urea + 14. According to Bland-Altman analysis, this formula showed the best performance for estimating osmolality. In children under 3 months of life Passing-Bablok regression indicated both systematic and proportional error for results obtained by each formula compared to the measured values.

Conclusions: To calculate osmolarity in children aged between 3 months and 2 years old the following equation: 1 .86*(N a + K) + 1.1 5*G lu+ U rea+ 14 might be used, whereas serum osmolality in children up to 3 month of life should be measured.

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儿童血清渗透压计算的准确性。

背景:血清渗透压可以测量(Omeas)或计算(Ocal)。Ocal的许多配方已经发表，但关于最准确的婴儿配方的数据还没有。因此，我们的目的是比较不同配方在新生儿和幼儿中获得的Omeas和Ocal。方法:在克拉科夫大学儿童医院接受治疗的280例儿童血清样本，从出生第一天到2岁(平均年龄8.2±7.6个月)。用渗透计测定血清渗透压，用8种常用公式计算血清渗透压。结果:除1.86*(N a + K) +1.15*Glu +尿素+ 14得到的Ocal外，各配方的平均值(2 8 5 .8±5.1 mOsm/kgH2O)与Ocal的平均值有显著差异(p< 0.01)。根据Bland-Altman分析，该公式对估算渗透压的性能最好。在3个月以下的儿童中，passingbablok回归表明，与测量值相比，每个公式获得的结果都存在系统误差和比例误差。结论:计算3个月至2岁儿童的血清渗透压可采用以下公式:1.86 *(N a+ K) + 1.1 5*G lu+ U rea+ 14，而3个月以下儿童的血清渗透压应测量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Medical Biochemistry BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

3.00

自引率

12.00%

发文量

审稿时长

>12 weeks

期刊介绍： The JOURNAL OF MEDICAL BIOCHEMISTRY (J MED BIOCHEM) is the official journal of the Society of Medical Biochemists of Serbia with international peer-review. Papers are independently reviewed by at least two reviewers selected by the Editors as Blind Peer Reviews. The Journal of Medical Biochemistry is published quarterly. The Journal publishes original scientific and specialized articles on all aspects of clinical and medical biochemistry, molecular medicine, clinical hematology and coagulation, clinical immunology and autoimmunity, clinical microbiology, virology, clinical genomics and molecular biology, genetic epidemiology, drug measurement, evaluation of diagnostic markers, new reagents and laboratory equipment, reference materials and methods, reference values, laboratory organization, automation, quality control, clinical metrology, all related scientific disciplines where chemistry, biochemistry, molecular biology and immunochemistry deal with the study of normal and pathologic processes in human beings.