Tissue healing changes on wounds in rats after treatment with Hancornia speciosa latex in cream-gel formulation.

IF 1.1 4区 医学 Q3 SURGERY Acta cirurgica brasileira Pub Date : 2022-01-01 DOI:10.1590/acb371001
Patrícia Lima D'Abadia, Susy Ricardo Lemes, Paulo Roberto de Melo-Reis, Ruy de Souza Lino Júnior, Pablo José Gonçalves, Diego Dos Santos Reis, Graziele Alícia Batista Caixeta, Vanessa Cristine Santana Amaral, Luciane Madureira Almeida
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Abstract

Purpose: Hancornia speciosa latex has shown pharmacological potential in wound healing processes due to its angiogenic, osteogenic, and anti-inflammatory activities. The aims of this study were to carry out a cream-gel formulation with 5, 10 and 25% of H. speciosa serum latex and to evaluate its potential to stimulate the skin regeneration in rats' wounds.

Methods: One hundred and twenty rats were divided into five groups: neutral control with saline (G1), cream-gel based on H. speciosa latex serum at 5% m/v (G2), cream-gel at 15% m/v (G3), cream-gel at 25% m/v (G4), and cream-gel (G5). The animals were euthanized at three, seven, 14 and 21 days after the injury induction, and some parameters were analyzed: wound contraction, necrosis, fibrin, polymorphonuclear and mononuclear infiltrates, fibroblast, angiogenesis, hemorrhage, and collagen.

Results: The therapeutic treatment with cream-gel at 15 and 25% is beneficial in the inflammatory phase of healing processes since it increased the angiogenesis and proliferation of mononuclear infiltrations in wounds. Regarding wound contraction, the treatment with cream-gel (5 and 15%) induced a higher rate of contraction in the proliferative phase. The 15% cream-gel formulation stimulated a greater production of collagen in the injured tissues.

Conclusions: H. speciosa cream-gel is a low-cost herbal medicine which can aid in tissue repair.

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霜凝胶配方的山楂胶乳对大鼠伤口组织愈合的影响。
目的:由于其血管生成、成骨和抗炎活性,山楂胶乳在伤口愈合过程中显示出潜在的药理作用。本研究的目的是建立一种含有5%、10%和25%特氏菌血清乳胶的乳凝胶配方,并评估其刺激大鼠伤口皮肤再生的潜力。方法:120只大鼠随机分为5组:生理盐水中性对照组(G1)、5% m/v的黄花乳剂乳凝胶组(G2)、15% m/v的乳凝胶组(G3)、25% m/v的乳凝胶组(G4)、乳凝胶组(G5)。分别于损伤诱导后第3、7、14、21天实施安乐死,分析创面收缩、坏死、纤维蛋白、多形核及单核浸润、成纤维细胞、血管生成、出血、胶原蛋白等参数。结果:15%和25%的乳凝胶治疗在愈合过程的炎症期是有益的,因为它增加了伤口的血管生成和单核浸润的增殖。在伤口收缩方面,乳凝胶治疗(5%和15%)在增殖期诱导了更高的收缩率。15%的奶油凝胶配方刺激了受伤组织中胶原蛋白的更多产生。结论:黄花蜜凝胶是一种具有组织修复作用的低成本中草药。
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来源期刊
CiteScore
1.90
自引率
9.10%
发文量
60
审稿时长
3-8 weeks
期刊介绍: Information not localized
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