EEG Characteristics Before and After Dexmedetomidine Treatment in Severe Patients: A Prospective Study.

IF 1.6 4区 医学 Q3 CLINICAL NEUROLOGY Clinical EEG and Neuroscience Pub Date : 2024-05-01 Epub Date: 2022-12-20 DOI:10.1177/15500594221144570
Yujie Ma, Hongbin Zhang, Jijia Bai, Jinyuan Zhu
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Abstract

Background. Bedside electroencephalography (EEG) can monitor the changes in brain function in critical patients. Light sedation is recommended in intensive care unit (ICU) patients, but sedation might confuse the EEG readings. There are few studies on the changes of EEG in severe patients with dexmedetomidine. This study aimed to explore the EEG characteristics before and after dexmedetomidine in severe patients in the ICU. Methods. This prospective study enrolled severe patients with sepsis who needed light sedation, we sedated the patients with dexmedetomidine. EEG was recorded for at least 60 min using a quantitative EEG (qEEG) bedside monitor. Amplitude-EEG (aEEG), relative spectral energy, alpha variation, and spectral entropy were recorded and compared before/after dexmedetomidine. Results. Sixty-three participants were enrolled. The relative spectral energy and alpha variation were not different before and after the use of dexmedetomidine (P> .05). The amplitude of the upper and lower boundaries in aEEG and spectral entropy were significantly lower after light sedation with dexmedetomidine compared with before (P< .05). When grouped according to the Glasgow Coma Scale (GCS), the amplitude of qEEG in participants with moderate GCS decreased significantly(P< .05), but not in mild or severe GCS. Conclusion. Relative spectral energy and alpha variation derived from qEEG could be used to evaluate the state of brain function even under light sedation with dexmedetomidine in severe patients during their ICU stay.

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重症患者右美托咪定治疗前后的脑电图特征:一项前瞻性研究
背景。床旁脑电图(EEG)可监测危重病人脑功能的变化。重症监护室(ICU)患者建议使用轻度镇静剂,但镇静剂可能会混淆脑电图读数。有关使用右美托咪定治疗重症患者脑电图变化的研究很少。本研究旨在探讨重症监护室重症患者使用右美托咪定前后的脑电图特征。方法。这项前瞻性研究招募了需要轻度镇静的重症脓毒症患者,我们使用右美托咪定对患者进行镇静。使用定量脑电图(qEEG)床旁监护仪记录至少 60 分钟的脑电图。记录并比较右美托咪定使用前后的振幅脑电图(aEEG)、相对频谱能量、α变异和频谱熵。结果。63 名参与者参加了研究。使用右美托咪定前后,相对频谱能量和阿尔法变化没有差异(P > .05)。使用右美托咪定进行轻度镇静后,aEEG 上下界振幅和频谱熵明显低于使用前(P .05)。根据格拉斯哥昏迷量表(GCS)分组时,中度 GCS 参与者的 qEEG 振幅明显下降(P .05),而轻度或重度 GCS 参与者的 qEEG 振幅则没有下降。结论即使在使用右美托咪定进行轻度镇静的情况下,重症患者在入住重症监护室期间的脑功能状态也可通过 qEEG 得出的相对频谱能量和α变异进行评估。
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来源期刊
Clinical EEG and Neuroscience
Clinical EEG and Neuroscience 医学-临床神经学
CiteScore
5.20
自引率
5.00%
发文量
66
审稿时长
>12 weeks
期刊介绍: Clinical EEG and Neuroscience conveys clinically relevant research and development in electroencephalography and neuroscience. Original articles on any aspect of clinical neurophysiology or related work in allied fields are invited for publication.
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