Survival Trend of Tuberculosis Patients and Risk Factors Associated with Mortality and Developing Drug-Resistant Tuberculosis in Hospital Pulau Pinang, Malaysia: A Retrospective Study.

IF 1.8 Q3 RESPIRATORY SYSTEM Advances in respiratory medicine Pub Date : 2022-11-14 DOI:10.3390/arm90060054

Aseel Rezeq Yaghi, Heba Saleh Shaheed, Sabariah Noor Harun, Irfhan Ali Hyder Ali, Amer Hayat Khan

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Abstract

Background: Multidrug resistance TB (MDR-TB) has emerged as a public health issue worldwide, and the mortality rate is worrying. Therefore, this study was conducted to investigate the factors related to MDR-TB occurrence and the survival experience of TB patients.

Methods: A retrospective cohort study was conducted at Hospital Pulau Pinang in Malaysia. Medical records of active TB patients from 2014-2018 were reviewed. Cox regression was used to identify the factors associated with MDR-TB development and mortality among TB patients.

Results: The patients had a mean age of 48.84 ± 16.713 years, and a majority of the Chinese race (46.4%). Out of 351 TB patients, 325 (92.6%) were drug-susceptible TB, and 26 (7.4%) were diagnosed with MDR-TB. Among drug-susceptible TB patients, 245 (75.4%) achieved successful outcomes, and 73 (22.5%) passed away. In multivariable Cox regression, drug addiction, levels of white blood cells, urea, platelets, and albumin were significantly associated with death. Relapsed TB, alcohol consumption, and being single were significant risk factors for MDR-TB development.

Conclusion: Patients achieved a success rate of 75.4%, which is encouraging but still far below the WHO target (at least an 85% success rate) and has room for further improvement.

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马来西亚普劳槟榔屿医院肺结核病人的生存趋势以及与死亡率和产生耐药性肺结核有关的风险因素：一项回顾性研究。

背景：耐多药结核病（MDR-TB）已成为全球公共卫生问题，其死亡率令人担忧。因此，本研究旨在调查与 MDR-TB 发生相关的因素以及结核病患者的生存经历：方法：在马来西亚的普劳槟榔屿医院开展了一项回顾性队列研究。研究回顾了 2014-2018 年间活动性肺结核患者的医疗记录。结果：患者平均年龄为48岁，平均病死率为1.5%：患者的平均年龄为（48.84 ± 16.713）岁，大部分为华裔（46.4%）。在 351 名肺结核患者中，325 人（92.6%）为药物敏感型肺结核，26 人（7.4%）被确诊为 MDR-TB 患者。在对药物敏感的肺结核患者中，245 人（75.4%）成功治愈，73 人（22.5%）去世。在多变量考克斯回归中，吸毒成瘾、白细胞、尿素、血小板和白蛋白水平与死亡显著相关。结核病复发、饮酒和单身是耐多药结核病发展的重要风险因素：患者的成功率为 75.4%，虽然令人鼓舞，但仍远低于世界卫生组织的目标（至少 85% 的成功率），仍有进一步提高的空间。

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来源期刊

Advances in respiratory medicine RESPIRATORY SYSTEM-

CiteScore

2.60

自引率

0.00%

发文量

期刊介绍： "Advances in Respiratory Medicine" is a new international title for "Pneumonologia i Alergologia Polska", edited bimonthly and addressed to respiratory professionals. The Journal contains peer-reviewed original research papers, short communications, case-reports, recommendations of the Polish Respiratory Society concerning the diagnosis and treatment of lung diseases, editorials, postgraduate education articles, letters and book reviews in the field of pneumonology, allergology, oncology, immunology and infectious diseases. "Advances in Respiratory Medicine" is an open access, official journal of Polish Society of Lung Diseases, Polish Society of Allergology and National Research Institute of Tuberculosis and Lung Diseases.