Lower Limb Salvage For Tumours Around The Knee Using Oncological Resections And Megaprosthetic Reconstructions.

Faridullah Khan Zimri, Muhammad Saaiq, Muhammad Noman, Faisal Qayyum
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Abstract

Background: This descriptive case series documented the clinical presentation of tumours around the knee in our population and explored the outcome of lower limb salvage with oncological resections and megaprosthetic reconstructions. The variables analysed included return of knee function, disease free survival and any complications observed over a follow up period of 5-years.

Methods: The study spanned over a period of 13-years. It included adult patients of all genders who presented with tumours around the knee and underwent tumour resections followed by megaprosthetic reconstructions at our institute.

Results: Out of 73 patients, there were 43 (58.90%) males and 30 (41.09%) females. Their ages ranged between 16-53 years with a mean of 32.97±10.68 years. The tumours included giant cell tumours (n=41), osteosarcomas (n=24), Spindle cell sarcoma (n=5), chondrosarcoma (n=2) and Ewing's sarcoma (n=1). The average postoperative musculoskeletal tumour society (MSTS) score was 84.65%. Various complications encountered included superficial infections/ delayed wound healing among 9 (12.32%) patients, local recurrence in 6 (8.21%), deep infections among 5 (6.84%) and transient palsy of peroneal nerve in 3 (4.10%) cases. There was aseptic loosening and traumatic disruption of extensor mechanism one each (1.36%). There were 7 (9.58%) mortalities in our series.

Conclusions: Giant cell tumours and osteosarcomas were the most frequent tumours observed around the knee. The tumours affected relatively younger population. Safe oncological resections of the tumours followed by megaprosthetic reconstructions provided reasonable outcome in the majority of patients.

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利用肿瘤切除和大型假体重建修复膝关节周围肿瘤的下肢保留。
背景:这个描述性的病例系列记录了我们人群中膝关节周围肿瘤的临床表现,并探讨了通过肿瘤切除和大型假体重建挽救下肢的结果。分析的变量包括膝关节功能恢复、无病生存率和随访5年期间观察到的任何并发症。方法:研究历时13年。它包括所有性别的成年患者,他们表现为膝盖周围的肿瘤,并在我们研究所接受肿瘤切除后进行大型假体重建。结果:73例患者中,男性43例(58.90%),女性30例(41.09%)。年龄16 ~ 53岁,平均32.97±10.68岁。肿瘤包括巨细胞瘤(41例)、骨肉瘤(24例)、梭形细胞肉瘤(5例)、软骨肉瘤(2例)和尤文氏肉瘤(1例)。术后肌肉骨骼肿瘤学会(MSTS)平均评分为84.65%。并发症包括浅表感染/伤口延迟愈合9例(12.32%),局部复发6例(8.21%),深部感染5例(6.84%),腓骨神经一过性麻痹3例(4.10%)。无菌性松脱和外伤性伸肌机制断裂各1例(1.36%)。在我们的研究中,有7例(9.58%)死亡。结论:巨细胞瘤和骨肉瘤是膝关节周围最常见的肿瘤。肿瘤影响相对较年轻的人群。在大多数患者中,安全的肿瘤切除后进行大型假体重建提供了合理的结果。
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