Genetic diversity of 15 STR loci in Yunnan Va ethnic minority and the phylogenetic relationships with 26 other populations.

IF 1.2 4区医学 Q2 ANTHROPOLOGY Annals of Human Biology Pub Date : 2022-12-01 DOI:10.1080/03014460.2022.2141854

Xiufeng Zhang, Jing Li, Jingtao Wen

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Abstract

Background: The Va (also called "Wa") people are an ethnic minority living mainly in the southwest of Yunnan Province.

Aim: This study was conducted to obtain the genetic information and forensic statistical parameters of 15 autosomal short tandem repeat (STR) loci included in the AmpFlSTR^®Identifiler™ kit (Applied Biosystems, Foster City, CA) in the Yunnan Va population, with a view to enriching the genetic databases of the Chinese Va population.

Subjects and methods: A total of 508 unrelated Chinese Va individuals were genotyped with this 15 STR kit, the genetic polymorphisms and associated forensic parameters were calculated. The genetic relationships between Chinese Va and 26 other Chinese populations were also evaluated.

Results: All of the STR loci reached the Hardy-Weinberg equilibrium after Bonferroni correction. A total of 159 alleles were observed with allele frequencies ranging from 0.000984 to 0.606299. The combined discrimination power (CDP) and the cumulative probability of excluding (CPE) of the 15 STR loci were 0.999 999 999 999 999 988 126 and 0.999 995 734, respectively. Our results indicated that the geographically adjacent or ethnically close populations showed a higher genetic affinity.

Conclusions: The results of this study will enrich the forensic databases of the Chinese Va population and could be applied in forensic analysis.

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云南佤族15个STR位点的遗传多样性及其与其他26个人群的系统发育关系

背景:佤族(又称佤族)是主要生活在云南省西南部的少数民族。目的:本研究旨在获取AmpFlSTR®Identifiler™试剂盒(Applied Biosystems, Foster City, CA)在云南Va人群中包含的15个常染色体短串联重复(STR)基因座的遗传信息和法医学统计参数，以期丰富中国Va人群的遗传数据库。对象和方法:用15str试剂盒对508例无亲缘关系的中国Va个体进行基因分型，计算遗传多态性及相关法医学参数。对中国Va与其他26个中国人群的亲缘关系进行了评价。结果:所有STR基因座经Bonferroni校正后均达到Hardy-Weinberg平衡。共检测到159个等位基因，等位基因频率在0.000984 ~ 0.606299之间。15个STR基因座的综合鉴别力(CDP)和累计排除概率(CPE)分别为0.999 999 999 999 999 988 126和0.999 995 734。结果表明，地理上相邻或种族上相近的种群具有较高的遗传亲和力。结论:本研究结果将丰富中国Va人群的法医学数据库，可用于法医学分析。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Human Biology 生物-公共卫生、环境卫生与职业卫生

CiteScore

3.40

自引率

5.90%

发文量

审稿时长

1 months

期刊介绍： Annals of Human Biology is an international, peer-reviewed journal published six times a year in electronic format. The journal reports investigations on the nature, development and causes of human variation, embracing the disciplines of human growth and development, human genetics, physical and biological anthropology, demography, environmental physiology, ecology, epidemiology and global health and ageing research.