Plant metabolite diosmin as the therapeutic agent in human diseases

Q2 Agricultural and Biological Sciences Current Research in Pharmacology and Drug Discovery Pub Date : 2022-01-01 DOI:10.1016/j.crphar.2022.100122

Saad Mustafa , Mahmood Akbar , Mohammad Aasif Khan , Kumari Sunita , Shabana Parveen , Jogendra Singh Pawar , Sheersh Massey , Nupur Rani Agarwal , Syed Akhtar Husain

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引用次数: 10

Abstract

Plant-derived flavonoids have been the focus of research for many years mainly in the last decade owing to their therapeutic properties. So far, about 4000 flavonoids have been identified from plants and diosmin (a flavone glycoside) is one of them. Online databases, previous studies, and reviews have been used to gather information on anti-oxidant, immunomodulatory, anti-cancer, anti-parasitic, and anti-microbialproperties of diosmin. Effects of diosmin in combination with other flavonoids have been reviewed thoroughly and its administrative routes are also summarized. Additionally, we studied the effect of diosmin on critical protein networks. It exhibits therapeutic effects in diabetes and its associated complications such as neuropathy and dyslipidemia. Combination of diosmin with hesperidin is found to be very effective in the treatment of chronic venous insufficiency and haemorrhoids. Diosmin is an exquisite therapeutic agent alone as well as in combination with other flavonoids.

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植物代谢物薯蓣皂苷作为人类疾病的治疗剂

植物源性黄酮类化合物近年来一直是研究的热点，主要是近十年来由于其治疗特性。迄今为止，已从植物中鉴定出约4000种黄酮类化合物，薯蓣皂苷(一种黄酮类苷)就是其中之一。在线数据库、先前的研究和综述已被用于收集薯蓣皂苷的抗氧化、免疫调节、抗癌、抗寄生虫和抗微生物特性的信息。综述了薯蓣皂苷与其他类黄酮的联用作用，并对其给药途径进行了综述。此外，我们还研究了薯蓣皂苷对关键蛋白质网络的影响。它对糖尿病及其相关并发症如神经病变和血脂异常有治疗作用。地奥司明与橙皮苷联合治疗慢性静脉功能不全和痔疮是非常有效的。薯蓣皂苷是一种精美的治疗剂单独以及与其他类黄酮的组合。

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