Sex dimorphism of weight and length at birth: evidence based on disorders of sex development.

IF 1.2 4区医学 Q2 ANTHROPOLOGY Annals of Human Biology Pub Date : 2022-12-01 DOI:10.1080/03014460.2022.2134452

Debora Stabile Romero Amais, Tainara Emilia Rodrigues da Silva, Beatriz Amstalden Barros, Juliana Gabriel Ribeiro de Andrade, Sofia Helena Valente de Lemos-Marini, Maricilda Palandi de Mello, Antonia Paula Marques- de-Faria, Tais Nitsch Mazzola, Mara Sanches Guaragna, Helena Fabbri-Scallet, Tarsis Antonio Paiva Vieira, Nilma Lucia Viguetti-Campos, Andre Moreno Morcillo, Olaf Hiort, Andrea Trevas Maciel-Guerra, Gil Guerra-Junior

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Abstract

Background: Males have higher weight and length at birth than females.

Aim: To verify the influence of the Y chromosome and the action of intrauterine androgens on weight and length at birth of children with Disorders of Sex Development (DSD).

Subjects and methods: A cross-sectional and retrospective study. Patients with Turner syndrome (TS), complete (XX and XY), mixed (45,X/46,XY) and partial (XY) gonadal dysgenesis (GD), complete (CAIS) and partial (PAIS) androgen insensitivity syndromes and XX and XY congenital adrenal hyperplasia (CAH) were included. Weight and length at birth were evaluated.

Results: Weight and length at birth were lower in TS and mixed GD when compared to XY and XX DSD cases. In turn, patients with increased androgen action (117 cases) had higher weight and length at birth when compared to those with absent (108 cases) and decreased (68 cases) production/action. In birthweight, there was a negative influence of the 45,X/46,XY karyotype and a positive influence of increased androgen and gestational age. In birth length, there was a negative influence of the 45,X and 45,X/46,XY karyotypes and also a positive influence of increased androgen and gestational age.

Conclusions: The sex dimorphism of weight and length at birth could possibly be influenced by intrauterine androgenic action.

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出生时体重和身高的性别二态性:基于性发育障碍的证据。

背景:男性出生时的体重和身高高于女性。目的:探讨性发育障碍(DSD)患儿出生时Y染色体及宫内雄激素对体重和身高的影响。研究对象和方法:横断面和回顾性研究。包括特纳综合征(TS)、完全性(XX和XY)、混合性(45、X/46、XY)和部分性(XY)性腺发育不良(GD)、完全性(CAIS)和部分性(PAIS)雄激素不敏感综合征以及XX和XY型先天性肾上腺增生(CAH)患者。评估出生时的体重和身高。结果:与XY和XX型DSD相比，TS和混合GD的出生时体重和身高较低。反过来，雄激素作用增加的患者(117例)出生时体重和身高高于没有雄激素作用的患者(108例)和产生/作用减少的患者(68例)。在出生体重方面，45、X/46、XY核型有负向影响，雄激素和胎龄增加有正向影响。在出生长度方面，45、X和45、X/46、XY核型有负向影响，雄激素和胎龄的增加也有正向影响。结论:胎儿出生时体重和身高的性别二态性可能受宫内雄激素作用的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Human Biology 生物-公共卫生、环境卫生与职业卫生

CiteScore

3.40

自引率

5.90%

发文量

审稿时长

1 months

期刊介绍： Annals of Human Biology is an international, peer-reviewed journal published six times a year in electronic format. The journal reports investigations on the nature, development and causes of human variation, embracing the disciplines of human growth and development, human genetics, physical and biological anthropology, demography, environmental physiology, ecology, epidemiology and global health and ageing research.