Effect of Several Naja atra Antivenom Injection Methods on the Rabbit Model of Naja naja atra Bite Poisoning.

IF 2.1 4区 医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Journal of Tropical Medicine Pub Date : 2023-02-20 eCollection Date: 2023-01-01 DOI:10.1155/2023/3253771
Jie Yang, Jin-Cheng Li, Zhou Huang, Dong-Ling Huang, Fan Wang, Wan-Xia Wei, Ji-Fei Nong, Feng Yang, Xue-Ling Lu, Jun-Rong Zhu, Wei Wang
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Abstract

Snakebite is a global public health concern, which often occurs in tropical and subtropical underdeveloped areas, but it is often neglected. In the southern China, Naja naja atra (Chinese cobra) is a common venomous snake that causes swelling and necrosis of local tissues, even amputation and death. Currently, the main therapy is the administration of Naja atra antivenom, which greatly reduces mortality. However, the antivenom is not particularly effective in the improvement of local tissue necrosis. Clinically, antivenom is mainly administered intravenously. We speculated that the method of injection influences the efficacy of antivenom. In this study, the rabbit model was used to explore the effects of different antivenom injection methods on systemic and local poisoning symptoms. If topical injection of antivenom contributes to ameliorate tissue necrosis, then we need to reconsider the use of Naja atra antivenom.

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几种 Naja atra 抗蛇毒血清注射方法对 Naja naja atra 咬伤中毒家兔模型的影响
毒蛇咬伤是一个全球性的公共卫生问题,经常发生在热带和亚热带欠发达地区,但往往被忽视。在中国南方,眼镜蛇是一种常见的毒蛇,被其咬伤后会导致局部组织肿胀、坏死,甚至截肢和死亡。目前,主要的治疗方法是注射眼镜蛇抗蛇毒血清,这可以大大降低死亡率。然而,抗蛇毒血清对改善局部组织坏死并不特别有效。临床上,抗蛇毒血清主要通过静脉注射。我们推测,注射方法会影响抗蛇毒血清的疗效。本研究以家兔为模型,探讨了不同抗蛇毒血清注射方法对全身和局部中毒症状的影响。如果局部注射抗蛇毒血清有助于改善组织坏死,那么我们就需要重新考虑使用 Naja atra 抗蛇毒血清。
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来源期刊
Journal of Tropical Medicine
Journal of Tropical Medicine Immunology and Microbiology-Parasitology
CiteScore
3.90
自引率
4.50%
发文量
0
审稿时长
14 weeks
期刊介绍: Journal of Tropical Medicine is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies on all aspects of tropical diseases. Articles on the pathology, diagnosis, and treatment of tropical diseases, parasites and their hosts, epidemiology, and public health issues will be considered. Journal of Tropical Medicine aims to facilitate the communication of advances addressing global health and mortality relating to tropical diseases.
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