Cardiometabolic syndrome in HIV-positive and HIV-negative patients at Zewditu Memorial Hospital, Addis Ababa, Ethiopia: a comparative cohort study.

IF 1.3 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Cardiovascular Endocrinology & Metabolism Pub Date : 2023-03-01 DOI:10.1097/XCE.0000000000000273
Minyahil Woldu, Omary Minzi, Workineh Shibeshi, Aster Shewaamare, Ephrem Engidawork
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Abstract

Cardiometabolic syndrome (CMetS) has recently emerged as a serious public health concern, particularly for individuals living with chronic conditions. This study aimed to determine the incidence and prevalence of CMetS, as well as the risk factors linked with it, in HIV-positive and HIV-negative adult patients.

Methods: A comparative cohort study was designed. The National Cholesterol Education Program (NCEP) and the International Diabetes Federation (IDF) tools were used to determine the outcome variables. Association studies were done using logistic regression.

Result: CMetS was found to have a greater point and period prevalence, and incidence estimation in HIV-negative than HIV+ patients using both the NCEP and the IDF tools. Using the NCEP tool, the risk of obesity was 44.1% [odds ratio (OR) = 0.559, 95% confidence interval (CI), (0.380-0.824); P = 0.003] lower in HIV+ than in HIV-negative participants. By contrast, no apparent difference was noted using the IDF tool. Similarly, hyperglycemia [OR = 0.651, 95% CI (0.457-0.926); P = 0.017], and hypertension [OR = 0.391, 95% CI (0.271-0.563); P < 0.001] were shown to be lower in HIV+ patients than HIV-negative patients by 34.9% and 60.9%, respectively. The study revealed significant variation in all biomarkers across the follow-up period in both HIV+ and HIV-negative participants, except for SBP.

Conclusions: CMetS caused more overall disruption in HIV-negative people with chronic diseases than in HIV-positive people. All of the indicators used to assess the increased risk of CMetS were equally meaningful in HIV+ and HIV-negative subjects.

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埃塞俄比亚亚的斯亚贝巴Zewditu纪念医院hiv阳性和hiv阴性患者的心脏代谢综合征:一项比较队列研究
心脏代谢综合征(CMetS)最近已成为一个严重的公共卫生问题,特别是对于患有慢性疾病的个体。本研究旨在确定hiv阳性和hiv阴性成人患者中CMetS的发病率和流行率,以及与之相关的危险因素。方法:设计比较队列研究。使用国家胆固醇教育计划(NCEP)和国际糖尿病联合会(IDF)工具来确定结果变量。关联研究采用逻辑回归进行。结果:使用NCEP和IDF工具,发现CMetS在HIV阴性患者中的点和期患病率和发病率估计高于HIV阳性患者。使用NCEP工具,肥胖的风险为44.1%[优势比(OR) = 0.559, 95%可信区间(CI), (0.380-0.824);P = 0.003]比HIV阴性参与者低。相比之下,使用IDF工具没有发现明显的差异。同样,高血糖[OR = 0.651, 95% CI (0.457-0.926);P = 0.017],高血压[OR = 0.391, 95% CI (0.271 ~ 0.563);P < 0.001], HIV阳性患者比HIV阴性患者分别低34.9%和60.9%。该研究显示,除了收缩压外,HIV阳性和HIV阴性参与者在整个随访期间的所有生物标志物都有显著变化。结论:CMetS在hiv阴性慢性疾病患者中比在hiv阳性患者中造成更大的总体破坏。用于评估cmet风险增加的所有指标在HIV+和HIV阴性受试者中同样有意义。
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来源期刊
Cardiovascular Endocrinology & Metabolism
Cardiovascular Endocrinology & Metabolism CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
5.60
自引率
0.00%
发文量
24
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