Glycemic Variability Within 1 Year Following Surgery for Stage II-III Colon Cancer.

IF 2.1 4区医学 Q2 NURSING Biological research for nursing Pub Date : 2022-01-01 DOI:10.1177/10998004211035184

Natalie Rasmussen Mandolfo, Ann M Berger, Leeza Struwe, Kathleen M Hanna, Whitney Goldner, Kelsey Klute, Sean Langenfeld, Marilyn Hammer

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Abstract

Objective: To examine glycemic variability within 1 month and 1 year following surgery among adult patients, with and without Type 2 Diabetes (T2D), treated for stage II-III colon cancer.

Method: A retrospective analysis of electronic health record data was conducted. Glycemic variability (i.e., standard deviation [SD] and coefficient of variation [CV] of > 2 blood glucose measures) was assessed within 1 month and within 1 year following colon surgery. Chi-square (χ²), Fisher's exact, and Mann-Whitney U tests were used for the analyses.

Results: Among the sample of 165 patients with stage II-III colon cancer, those with T2D had higher glycemic variability compared to patients without T2D (p < .001), with values within 1 month following surgery (SD = 44.69 mg/dL, CV = 27.4%) vs (SD = 20.55 mg/dL, CV = 17.53%); and within 1 year following surgery (SD = 45.04 mg/dL, CV = 29.04%) vs (SD = 21.36 mg/dL, CV = 18.6%). Associations were found between lower body mass index and higher glycemic variability (i.e., SD [r = -.413, p < .05] and CV [r = -.481, p < .01]) within 1 month following surgery in patients with T2D. Higher preoperative glucose was associated with higher glycemic variability (i.e., SD r = .448, p < .01) within 1 year in patients with T2D. Demographic and clinical characteristics were weakly associated with glycemic variability in patients without T2D.

Conclusions: Patients with stage II-III colon cancer with T2D experienced higher glycemic variability within 1 month and within 1 year following surgery compared to those without T2D. Associations between glycemic variability and demographic and clinical characteristics differed by T2D status. Further research in prospective studies is warranted.

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II-III期结肠癌术后1年内的血糖变异性。

目的:研究II-III期结肠癌治疗的2型糖尿病(T2D)成年患者术后1个月和1年内的血糖变异性。方法:对电子病历资料进行回顾性分析。在结肠手术后1个月内和1年内评估血糖变异性(即> 2项血糖测量的标准差[SD]和变异系数[CV])。采用χ2、Fisher精确检验和Mann-Whitney U检验进行分析。结果:在165例II-III期结肠癌患者样本中，T2D患者的血糖变异性高于无T2D患者(p < 0.001)，其值在术后1个月内(SD = 44.69 mg/dL, CV = 27.4%) vs (SD = 20.55 mg/dL, CV = 17.53%);术后1年内(SD = 45.04 mg/dL, CV = 29.04%) vs (SD = 21.36 mg/dL, CV = 18.6%)。发现较低的体重指数与较高的血糖变异性(即SD [r = -])之间存在关联。413, p .05]和CV [r = -。[481, p .01])。术前较高的血糖水平与T2D患者1年内较高的血糖变异性相关(即标准差r = 0.448, p .01)。非t2dm患者的人口学和临床特征与血糖变异性相关性较弱。结论:II-III期结肠癌合并T2D患者术后1个月和1年内血糖变异性高于未合并T2D的患者。血糖变异性与人口学和临床特征之间的关系因糖尿病状态而异。进一步的前瞻性研究是必要的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biological research for nursing 医学-护理

CiteScore

5.10

自引率

4.00%

发文量

审稿时长

>12 weeks

期刊介绍： Biological Research For Nursing (BRN) is a peer-reviewed quarterly journal that helps nurse researchers, educators, and practitioners integrate information from many basic disciplines; biology, physiology, chemistry, health policy, business, engineering, education, communication and the social sciences into nursing research, theory and clinical practice. This journal is a member of the Committee on Publication Ethics (COPE)