DNA damage and metabolic mechanisms of cancer drug resistance.

IF 4.6 Q1 ONCOLOGY 癌症耐药(英文) Pub Date : 2022-01-01 DOI:10.20517/cdr.2021.148
Deanna Tiek, Shi-Yuan Cheng
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引用次数: 3

Abstract

Cancer drug resistance is one of the main barriers to overcome to ensure durable treatment responses. While many pivotal advances have been made in first combination therapies, then targeted therapies, and now broadening out to immunomodulatory drugs or metabolic targeting compounds, drug resistance is still ultimately universally fatal. In this brief review, we will discuss different strategies that have been used to fight drug resistance from synthetic lethality to tumor microenvironment modulation, focusing on the DNA damage response and tumor metabolism both within tumor cells and their surrounding microenvironment. In this way, with a better understanding of both targetable mutations in combination with the metabolism, smarter drugs may be designed to combat cancer drug resistance.

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肿瘤耐药的DNA损伤及代谢机制。
癌症耐药是确保持久治疗反应需要克服的主要障碍之一。虽然在联合治疗和靶向治疗方面取得了许多关键进展,现在又扩展到免疫调节药物或代谢靶向化合物,但耐药性最终仍是普遍致命的。在这篇简短的综述中,我们将讨论用于对抗耐药性的不同策略,从合成致死性到肿瘤微环境调节,重点关注肿瘤细胞及其周围微环境中的DNA损伤反应和肿瘤代谢。通过这种方式,更好地了解这两种靶向突变与代谢的结合,可以设计出更聪明的药物来对抗癌症耐药性。
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CiteScore
6.60
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