Association Between Sex Hormone-Binding Globulin, Atherogenic Indices of Plasma Among Young Sedentary Males.

IF 2.3 Q3 NUTRITION & DIETETICS Nutrition and Metabolic Insights Pub Date : 2023-02-23 eCollection Date: 2023-01-01 DOI:10.1177/11786388231155006
Ali Mohammadrezaei, Abnoos Mokhtari Ardekani, Mahdieh Abbasalizad-Farhangi, Mehran Mesgari-Abbasi, Reihaneh Mousavi
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Abstract

Background: Males are more likely than females to suffer from cardiovascular disease (CVD). So, sex hormones may modify these variations and affect the lipid profile. We examined the relationship between sex hormone-binding globulin (SHBG) and CVD risk factors among young males in this study.

Methods: Using a cross-sectional design, we measured total testosterone, SHBG, lipids, glucose, insulin, antioxidant parameters, and anthropometric factors in 48 young males in the age range of 18 to 40 years. Atherogenic indices of plasma were calculated. In this study, a partial correlation analysis was carried out to assess the relationship between SHBG and other variables after adjustment for confounders.

Results: According to the results of multivariable analyses adjusted for age and energy, SHBG had a negative correlation with total cholesterol (r = -.454, P =.010), low-density lipoprotein cholesterol (r = -.496, P =.005), quantitative insulin-sensitivity check index, and positive correlation with high-density lipoprotein cholesterol (r = .463, P =.009). No significant correlation was observed between SHBG and triglycerides (P >.05). Several atherogenic indices of plasma have a negative correlation with SHBG levels. These include Atherogenic Index of Plasma (r = -.474, P = .006), Castelli Risk Index (CRI)1 (r = -.581, P < .001), CRI2 (r = -.564, P = .001), and Atherogenic Coefficient (r = -.581, P < .001).

Conclusion: Among young men, high plasma SHBG was associated with reduced CVD risk factors, modified lipid profile and atherogenic ratios, and better glycemic markers. Therefore, reduced SHBG concentrations could be a prognostic marker of CVD among young sedentary males.

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久坐不动的年轻男性血浆中性激素结合球蛋白与致动脉粥样硬化指数之间的关系
背景:男性比女性更容易罹患心血管疾病(CVD)。因此,性激素可能会改变这些变化并影响血脂状况。本研究探讨了性激素结合球蛋白(SHBG)与年轻男性心血管疾病风险因素之间的关系:我们采用横断面设计,测量了 48 名 18 至 40 岁年轻男性的总睾酮、SHBG、血脂、血糖、胰岛素、抗氧化参数和人体测量因素。计算了血浆中的致动脉粥样硬化指数。在这项研究中,对混杂因素进行调整后,进行了部分相关性分析,以评估 SHBG 与其他变量之间的关系:根据年龄和能量调整后的多变量分析结果,SHBG 与总胆固醇(r = -.454,P =.010)、低密度脂蛋白胆固醇(r = -.496,P =.005)、胰岛素敏感性定量检查指数呈负相关,与高密度脂蛋白胆固醇呈正相关(r = .463,P =.009)。在 SHBG 和甘油三酯之间没有观察到明显的相关性(P >.05)。血浆中的一些致动脉粥样硬化指数与 SHBG 水平呈负相关。这些指数包括血浆致动脉粥样硬化指数(r = -.474,P = .006)、卡斯泰利风险指数(CRI)1(r = -.581,P r = -.564,P = .001)和致动脉粥样硬化系数(r = -.581,P 结论:SHBG 与血浆致动脉粥样硬化指数呈负相关:在年轻男性中,高血浆 SHBG 与心血管疾病风险因素的减少、血脂状况和致动脉粥样硬化比率的改变以及血糖指标的改善有关。因此,SHBG浓度降低可能是久坐不动的年轻男性心血管疾病的预后标志。
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来源期刊
Nutrition and Metabolic Insights
Nutrition and Metabolic Insights NUTRITION & DIETETICS-
CiteScore
3.30
自引率
0.00%
发文量
27
审稿时长
8 weeks
期刊介绍: Nutrition and Metabolic Insights is a peer-reviewed, open-access online journal focusing on all aspects of nutrition and metabolism. This encompasses nutrition, including the biochemistry of metabolism, exercise and associated physical processes and also includes clinical articles that relate to metabolism, such as obesity, lipidemias and diabetes. It includes research at the molecular, cellular and organismal levels. This journal welcomes new manuscripts for peer review on the following topics: Nutrition, including the biochemistry of metabolism, Exercise and associated physical processes, Clinical articles that relate to metabolism, such as obesity, lipidemias and diabetes, Research at the molecular, cellular and organismal levels, Other areas of interest include gene-nutrient interactions, the effects of hormones, models of metabolic function, macronutrient interactions, outcomes of changes in diet, and pathophysiology.
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