Journey to the other side of the brain: asymmetry in patients with chronic mild or moderate traumatic brain injury.

Q3 Medicine Concussion Pub Date : 2022-12-01 DOI:10.2217/cnc-2022-0003

David E Ross, John D Seabaugh, Jan M Seabaugh, Claudia Alvarez, Laura Peyton Ellis, Christopher Powell, Christopher Reese, Leah Cooper, Katherine Shepherd, For The Alzheimer's Disease Neuroimaging Initiative

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Abstract

Aim: Patients with chronic mild or moderate traumatic brain injury have some regions of brain atrophy (including cerebral white matter) but even more regions of abnormal brain enlargement (including other cerebral regions).

Hypothesis: Ipsilateral injury and atrophy cause the eventual development of contralateral compensatory hypertrophy.

Materials & methods: 50 patients with mild or moderate traumatic brain injury were compared to 80 normal controls (n = 80) with respect to MRI brain volume asymmetry. Asymmetry-based correlations were used to test the primary hypothesis.

Results: The group of patients had multiple regions of abnormal asymmetry.

Conclusion: The correlational analyses supported the conclusion that acute injury to ipsilateral cerebral white matter regions caused atrophy, leading eventually to abnormal enlargement of contralateral regions due to compensatory hypertrophy.

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前往大脑另一侧的旅程:慢性轻度或中度创伤性脑损伤患者的不对称性。

目的:慢性轻中度外伤性脑损伤患者有部分脑萎缩区(包括脑白质)，但更多的脑异常增大区(包括其他脑区)。假设:同侧损伤和萎缩导致对侧代偿性肥大的最终发展。材料与方法:将50例轻中度创伤性脑损伤患者与80例正常对照(n = 80)进行MRI脑容量不对称的比较。基于不对称的相关性被用来检验主要假设。结果:本组患者出现多处不对称异常。结论:相关分析支持同侧脑白质区急性损伤导致脑白质萎缩，最终导致对侧脑白质区代偿性肥厚异常增大的结论。

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