Clinical value of the platelet and inflammatory factor activation in vascular endothelial injury in essential hypertension.

IF 2.1 4区医学 Q3 HEMATOLOGY Clinical hemorheology and microcirculation Pub Date : 2023-01-01 DOI:10.3233/CH-221638

Zheng-Wei Jian, Xiao-Ming Zhang, Guan-Shen Huang

{"title":"Clinical value of the platelet and inflammatory factor activation in vascular endothelial injury in essential hypertension.","authors":"Zheng-Wei Jian, Xiao-Ming Zhang, Guan-Shen Huang","doi":"10.3233/CH-221638","DOIUrl":null,"url":null,"abstract":"Objective: To investigate the clinical value of platelet and inflammatory factor activation in vascular endothelial injury in hypertension.Methods: A total of 120 hypertension patients diagnosed in our hospital from December 2019 to June 2021 were enrolled as study objects (Hypertension group); besides, another cohort of 60 healthy people undergoing physical examination at the same period were recruited as the controls (Control group). Next, the baseline clinical characteristics of subjects in the two groups were recorded and compared. Specifically, a hematology analyzer was adopt for detecting the mean platelet volume (MPV), platelet distribution width (PDW) and platelet hematocrit (PCT); ELISA for the level of IL-6, IL-8 and TNF-α; PHILIPS EPIQ 7 C (a device assessing endothelial vasodilator function in a non-invasive fashion) for reactive hyperemia index (RHI); univariate and multivariate regression analysis for risk factors triggering endothelial dysfunction; and Spearman correlation analysis for the correlation of platelet activation indicators and inflammatory factor level with vascular endothelial function.Results: Compared with the Control group, the patients in the Hypertension group exhibited higher levels of MPV, PDW, PCT, inflammatory factors (IL-6, IL-8 and TNF-α) and lower RHI. Moreover, Spearman correlation analysis showed a significant negative correlation of MPV, PDW, PCT, IL-6, IL-8 and TNF-α level with RHI level. In addition, univariate and multivariate regression analysis presented that MPV, PCT, IL-8 and TNF-α were risk factors for vascular endothelial dysfunction.Conclusion: The activation of platelet and inflammatory factor is closely related to vascular endothelial function injury in patients with hypertension. To be specifically, platelet and inflammatory factor activation can effectively reflect the vascular endothelial function injury in patients with hypertension and has high clinical value.","PeriodicalId":10425,"journal":{"name":"Clinical hemorheology and microcirculation","volume":"83 2","pages":"171-180"},"PeriodicalIF":2.1000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical hemorheology and microcirculation","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3233/CH-221638","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"HEMATOLOGY","Score":null,"Total":0}

引用次数: 3

Abstract

Objective: To investigate the clinical value of platelet and inflammatory factor activation in vascular endothelial injury in hypertension.

Methods: A total of 120 hypertension patients diagnosed in our hospital from December 2019 to June 2021 were enrolled as study objects (Hypertension group); besides, another cohort of 60 healthy people undergoing physical examination at the same period were recruited as the controls (Control group). Next, the baseline clinical characteristics of subjects in the two groups were recorded and compared. Specifically, a hematology analyzer was adopt for detecting the mean platelet volume (MPV), platelet distribution width (PDW) and platelet hematocrit (PCT); ELISA for the level of IL-6, IL-8 and TNF-α; PHILIPS EPIQ 7 C (a device assessing endothelial vasodilator function in a non-invasive fashion) for reactive hyperemia index (RHI); univariate and multivariate regression analysis for risk factors triggering endothelial dysfunction; and Spearman correlation analysis for the correlation of platelet activation indicators and inflammatory factor level with vascular endothelial function.

Results: Compared with the Control group, the patients in the Hypertension group exhibited higher levels of MPV, PDW, PCT, inflammatory factors (IL-6, IL-8 and TNF-α) and lower RHI. Moreover, Spearman correlation analysis showed a significant negative correlation of MPV, PDW, PCT, IL-6, IL-8 and TNF-α level with RHI level. In addition, univariate and multivariate regression analysis presented that MPV, PCT, IL-8 and TNF-α were risk factors for vascular endothelial dysfunction.

Conclusion: The activation of platelet and inflammatory factor is closely related to vascular endothelial function injury in patients with hypertension. To be specifically, platelet and inflammatory factor activation can effectively reflect the vascular endothelial function injury in patients with hypertension and has high clinical value.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

原发性高血压患者血管内皮损伤中血小板和炎症因子活化的临床价值。

目的:探讨血小板和炎症因子活化在高血压血管内皮损伤中的临床价值。方法:选取2019年12月至2021年6月在我院确诊的高血压患者120例作为研究对象(高血压组);另招募同期体检的健康人群60人作为对照组(对照组)。然后，记录两组受试者的基线临床特征并进行比较。其中，采用血液学分析仪检测血小板平均体积(MPV)、血小板分布宽度(PDW)和血小板红细胞压积(PCT);ELISA检测IL-6、IL-8、TNF-α水平;PHILIPS EPIQ 7c(一种以无创方式评估内皮血管扩张剂功能的装置)用于反应性充血指数(RHI);内皮功能障碍危险因素的单因素和多因素回归分析血小板活化指标及炎症因子水平与血管内皮功能的相关性进行Spearman相关分析。结果:与对照组相比，高血压组患者MPV、PDW、PCT、炎症因子(IL-6、IL-8、TNF-α)水平升高，RHI降低。Spearman相关分析显示MPV、PDW、PCT、IL-6、IL-8、TNF-α水平与RHI水平呈显著负相关。单因素和多因素回归分析显示MPV、PCT、IL-8和TNF-α是血管内皮功能障碍的危险因素。结论:高血压患者血小板和炎症因子的活化与血管内皮功能损伤密切相关。具体来说，血小板和炎症因子活化能有效反映高血压患者血管内皮功能损伤情况，具有较高的临床价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Clinical hemorheology and microcirculation 医学-外周血管病

CiteScore

4.30

自引率

33.30%

发文量

170

期刊介绍： Clinical Hemorheology and Microcirculation, a peer-reviewed international scientific journal, serves as an aid to understanding the flow properties of blood and the relationship to normal and abnormal physiology. The rapidly expanding science of hemorheology concerns blood, its components and the blood vessels with which blood interacts. It includes perihemorheology, i.e., the rheology of fluid and structures in the perivascular and interstitial spaces as well as the lymphatic system. The clinical aspects include pathogenesis, symptomatology and diagnostic methods, and the fields of prophylaxis and therapy in all branches of medicine and surgery, pharmacology and drug research. The endeavour of the Editors-in-Chief and publishers of Clinical Hemorheology and Microcirculation is to bring together contributions from those working in various fields related to blood flow all over the world. The editors of Clinical Hemorheology and Microcirculation are from those countries in Europe, Asia, Australia and America where appreciable work in clinical hemorheology and microcirculation is being carried out. Each editor takes responsibility to decide on the acceptance of a manuscript. He is required to have the manuscript appraised by two referees and may be one of them himself. The executive editorial office, to which the manuscripts have been submitted, is responsible for rapid handling of the reviewing process. Clinical Hemorheology and Microcirculation accepts original papers, brief communications, mini-reports and letters to the Editors-in-Chief. Review articles, providing general views and new insights into related subjects, are regularly invited by the Editors-in-Chief. Proceedings of international and national conferences on clinical hemorheology (in original form or as abstracts) complete the range of editorial features.