Thalamocortical functional connectivity in youth with attention-deficit/hyperactivity disorder.

IF 4.1 2区 医学 Q2 NEUROSCIENCES Journal of Psychiatry & Neuroscience Pub Date : 2023-01-01 DOI:10.1503/jpn.220109
Soon-Beom Hong
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引用次数: 1

Abstract

Background: Few studies have empirically tested the relationships between anatomically defined thalamic nuclei and functionally defined cortical networks, and little is known about their implications in attention-deficit/hyperactivity disorder (ADHD). This study aimed to investigate the functional connectivity of the thalamus in youth with ADHD, using both anatomically and functionally defined thalamic seed regions.

Methods: Resting-state functional MRIs obtained from the publicly available ADHD-200 database were analyzed. Thalamic seed regions were defined functionally and anatomically based on Yeo's 7 resting-state-network parcellation atlas and the AAL3 atlas, respectively. Functional connectivity maps of the thalamus were extracted, and thalamocortical functional connectivity was compared between youth with and without ADHD.

Results: Using the functionally defined seeds, significant group differences in thalamocortical functional connectivity and significant negative correlations between thalamocortical connectivity and ADHD symptom severity were observed within the boundaries of corresponding large-scale networks. However, in the analysis using the anatomically defined thalamic seeds, significant group differences in connectivity and significant positive correlations were observed outside the expected boundaries of major anatomic projections. The thalamocortical connectivity originating from the lateral geniculate nuclei of the thalamus was significantly correlated with age in youth with ADHD.

Limitations: The small sample size and smaller proportion of girls were limiting factors.

Conclusion: Thalamocortical functional connectivity based on the intrinsic network architecture of the brain appears to be clinically relevant in ADHD. The positive association between thalamocortical functional connectivity and ADHD symptom severity may represent a compensatory process recruiting an alternative neural network.

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青少年注意缺陷/多动障碍的丘脑皮质功能连通性。
背景:很少有研究对解剖定义的丘脑核和功能定义的皮层网络之间的关系进行实证检验,并且对它们在注意缺陷/多动障碍(ADHD)中的意义知之甚少。本研究旨在利用解剖学和功能上定义的丘脑种子区来研究青少年多动症丘脑的功能连通性。方法:分析从公开的ADHD-200数据库中获得的静息状态功能核磁共振成像。基于Yeo's 7静息状态网络分割图谱和AAL3图谱,分别对丘脑种子区进行了功能和解剖上的定义。提取了丘脑的功能连接图,并比较了有和没有多动症的青少年的丘脑皮质功能连接。结果:使用功能定义的种子,在相应的大规模网络边界内,观察到丘脑皮质功能连通性的组间显著差异,以及丘脑皮质连通性与ADHD症状严重程度的显著负相关。然而,在使用解剖学定义的丘脑种子进行分析时,在主要解剖投影的预期边界之外观察到显著的组间连通性差异和显著的正相关性。来自丘脑外侧膝状核的丘脑皮质连通性与青少年ADHD患者的年龄显著相关。局限性:样本量小,女生比例小是限制因素。结论:基于大脑内在网络结构的丘脑皮质功能连通性似乎与ADHD临床相关。丘脑皮质功能连通性与ADHD症状严重程度之间的正相关可能代表了一个代偿过程,需要一个替代的神经网络。
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来源期刊
CiteScore
6.80
自引率
2.30%
发文量
51
审稿时长
2 months
期刊介绍: The Journal of Psychiatry & Neuroscience publishes papers at the intersection of psychiatry and neuroscience that advance our understanding of the neural mechanisms involved in the etiology and treatment of psychiatric disorders. This includes studies on patients with psychiatric disorders, healthy humans, and experimental animals as well as studies in vitro. Original research articles, including clinical trials with a mechanistic component, and review papers will be considered.
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