The Role of Substance P, Neurokinin A, Neuropeptide Y, and Cortisol in Assessing Neonatal Pain.

IF 0.6 Q4 NURSING Neonatal Network Pub Date : 2023-03-01 DOI:10.1891/NN.2022-0006

Christina Dionysakopoulou, Loukia Lianou, Barbara Boutopoulou, Margarita Giannakopoulou, Efrosini Vlachioti, Despoina Koumpagioti, Evangelos Bozas, Vasiliki Matziou

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Abstract

Introduction: Our aim was to investigate biomarkers of neonatal pain and their association with two pain scales. Methods: This prospective study included 54 full-term neonates. Levels of substance P (SubP), neurokinin A (NKA), neuropeptide Y (NPY), and cortisol were recorded and two pain scales (Premature Infant Pain Profile [PIPP] and Neonatal Infant Pain Scale [NIPS]) were used. Results: A statistically significant decrease in the levels of NPY (p = 0.02) and NKA (p = 0.03) was detected. A significant increase in NIPS scale (p < 0.001) and PIPP scale (p < 0.001) postpainful intervention was also detected. There was a positive correlation between cortisol and SubP (p = 0.01), NKA and NPY (p < 0.001) and between NIPS and PIPP (p < 0.001). A negative correlation was found for NPY with SubP (p = 0.004), cortisol (p = 0.02), NIPS (p = 0.001) and PIPP (p = 0.002). Conclusions: Novel biomarkers and pain scales may help in designing an objective tool for the quantification of neonatal pain in the everyday practice.

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P物质、神经激肽A、神经肽Y和皮质醇在评估新生儿疼痛中的作用。

我们的目的是研究新生儿疼痛的生物标志物及其与两种疼痛量表的关系。方法:本前瞻性研究纳入54例足月新生儿。记录P物质(SubP)、神经激肽A (NKA)、神经肽Y (NPY)和皮质醇的水平，并使用两种疼痛量表(早产儿疼痛量表[PIPP]和新生儿疼痛量表[NIPS])。结果:NPY (p = 0.02)、NKA (p = 0.03)显著降低。疼痛干预后NIPS量表(p < 0.001)和PIPP量表(p < 0.001)均显著升高。皮质醇与SubP (p = 0.01)、NKA与NPY (p < 0.001)、NIPS与PIPP (p < 0.001)呈正相关。NPY与SubP (p = 0.004)、皮质醇(p = 0.02)、NIPS (p = 0.001)和PIPP (p = 0.002)呈负相关。结论:新的生物标志物和疼痛量表可能有助于在日常实践中设计一个客观的量化新生儿疼痛的工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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