Genetic polymorphisms of 17 X-STR loci in two Tunisian populations from Sousse and Makthar.

IF 1.2 4区医学 Q2 ANTHROPOLOGY Annals of Human Biology Pub Date : 2022-12-01 DOI:10.1080/03014460.2022.2136755

Abir Mejri, Miriam Baeta, Rim Al-Haj-Taib, Rene J Herrera, Amel Benammar-Elgaaied, Marian M de Pancorbo, Karima Fadhlaoui-Zid

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引用次数: 1

Abstract

Background: Tunisia has a complex demographic history of migrations from within Africa, Europe, and the Middle East. However, only one population study based on X-STR markers has been reported so far.

Aim: To investigate the genetic polymorphisms of 17 X-STRs in two Tunisian populations from the cities of Sousse and Makthar, and to reveal the genetic relationships with other reference populations.

Subjects and methods: A total of 194 unrelated healthy individuals were analysed for 17 X-STR markers.

Results: Our results indicate that DXS6809 is the most polymorphic locus, whereas DXS6807 is the least informative marker in the populations of Sousse and Makthar. In addition, forensic statistical parameters, such as the power of discrimination in males and females, as well as the mean of exclusion in duos and trios, reveal that the panel of 17 X-STRs is highly informative and useful in different forensic applications. Overall, pairwise genetic distances (Fst) and non-metric MDS plots demonstrate clustering of different populations according to their geographic locations and their historical relationships.

Conclusion: Overall, the study of X-STR markers of the Tunisian populations can help to promote the establishment of a forensic DNA reference database in Tunisia and provide reference for future anthropological research.

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苏塞和马克塔尔两个突尼斯人群中17个X-STR位点的遗传多态性

背景:突尼斯有着来自非洲、欧洲和中东的复杂人口迁移历史。然而，目前仅报道了一项基于X-STR标记的人群研究。目的:研究突尼斯苏塞和马克塔尔两个人群中17个X-STRs的遗传多态性，并揭示其与其他参考人群的遗传关系。对象和方法:对194例无亲缘关系的健康人进行17种X-STR标记分析。结果:在Sousse和Makthar群体中，DXS6809是多态性最多的标记，而DXS6807是信息最少的标记。此外，法医统计参数，如男性和女性的歧视能力，以及二人组和三人组的排除平均值，表明17个x - str的面板在不同的法医应用中具有很高的信息量和实用性。总体而言，两两遗传距离(Fst)和非度量MDS图显示了不同种群根据其地理位置和历史关系的聚类。结论:总体而言，突尼斯人群X-STR标记的研究有助于促进突尼斯法医DNA参考数据库的建立，为今后的人类学研究提供参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Human Biology 生物-公共卫生、环境卫生与职业卫生

CiteScore

3.40

自引率

5.90%

发文量

审稿时长

1 months

期刊介绍： Annals of Human Biology is an international, peer-reviewed journal published six times a year in electronic format. The journal reports investigations on the nature, development and causes of human variation, embracing the disciplines of human growth and development, human genetics, physical and biological anthropology, demography, environmental physiology, ecology, epidemiology and global health and ageing research.