The effects of glucocorticoid treatment on cardiovascular system in patients with systemic lupus erythematosus.

IF 1.1 4区医学 Q4 Medicine Archives of rheumatology Pub Date : 2022-12-01 DOI:10.46497/ArchRheumatol.2022.9255

Dominika Blachut, Brygida Przywara-Chowaniec, Jan Harpula, Andrzej Tomasik, Ewa Nowalany-Kozielska, Beata Morawiec

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Abstract

Objectives: This study aims to assess variables concerning arterial stiffness including carotid-femoral pulse wave velocity, carotid-radial pulse wave velocity, ankle-brachial index, and the advancement of atherosclerosis development.

Patients and methods: Between October 2016 and December 2020, a total of 43 consecutive patients with systemic lupus erythematosus (SLE) (4 males, 39 females; mean age: 57±8 years; range, 42 to 65 years) were prospectively included in the study. All data were compared between the group treated with glucocorticoids and that not treated with these agents.

Results: The study group consisted of 43 patients with SLE, while 22 (51%) patients were treated with glucocorticoids. The mean duration of SLE was 12.3±5.3 years. Patients treated with glucocorticoids had lower values of ankle-brachial index compared to those who were not treated with glucocorticoids (p=0.041), although the values were within the range. A similar situation was reported for the carotid-femoral artery pulse wave velocity (p=0.032). However, carotid-radial artery pulse wave velocity was not significantly different between both groups (p=0.12).

Conclusion: Properly selected therapy is important in the prevention of CVD.

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糖皮质激素治疗对系统性红斑狼疮患者心血管系统的影响。

目的:本研究旨在评估动脉硬度的变量，包括颈动脉-股动脉脉波速度、颈动脉-桡动脉脉波速度、踝-肱指数和动脉粥样硬化发展的进展。患者和方法:2016年10月至2020年12月，共连续43例系统性红斑狼疮(SLE)患者(男4例，女39例;平均年龄:57±8岁;年龄范围42 - 65岁)被纳入前瞻性研究。所有数据在接受糖皮质激素治疗组和未接受糖皮质激素治疗组之间进行比较。结果:研究组有43例SLE患者，其中22例(51%)患者接受糖皮质激素治疗。SLE平均病程12.3±5.3年。与未接受糖皮质激素治疗的患者相比，接受糖皮质激素治疗的患者踝臂指数较低(p=0.041)，尽管其值在范围内。颈动脉-股动脉脉波速度也有类似的情况(p=0.032)。两组间颈桡动脉脉波速度差异无统计学意义(p=0.12)。结论:合理选择治疗方法是预防心血管疾病的重要手段。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of rheumatology Medicine-Rheumatology

CiteScore

2.00

自引率

9.10%

发文量

期刊介绍： The Archives of Rheumatology is an official journal of the Turkish League Against Rheumatism (TLAR) and is published quarterly in March, June, September, and December. It publishes original work on all aspects of rheumatology and disorders of the musculoskeletal system. The priority of the Archives of Rheumatology is to publish high-quality original research articles, especially in inflammatory rheumatic disorders. In addition to research articles, brief reports, reviews, editorials, letters to the editor can also be published. It is an independent peer-reviewed international journal printed in English. Manuscripts are refereed by a "double-blind peer-reviewed" process for both referees and authors. Editorial Board of the Archives of Rheumatology works under the principles of The World Association of Medical Editors (WAME), the International Council of Medical Journal Editors (ICMJE), and Committee on Publication Ethics (COPE).