Alteration in Serum Levels of Tumor Necrosis Factor Alpha is associated with Histopathologic Progression of Gastric Cancer

Q2 Biochemistry, Genetics and Molecular Biology Iranian Biomedical Journal Pub Date : 2023-01-01 DOI:10.52547/ibj.3847

Mehdi Alikhani, Maryam Esmaeili, Mohammad Tashakoripour, Mohammad Ali Mohagheghi, Mahmoud Eshagh Hosseini, Eliette Touati, Massoud Vosough, Marjan Mohammadi

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引用次数: 2

Abstract

Background: The role of inflammatory cytokines, such as tumor necrosis-α (TNF-α) and IL-8, in gastric carcinogenesis has been investigated, but their impact remains to be further elucidated.

Methods: In this study, we measured the serum concentrations of these cytokines and H. pylori serostatus in dyspeptic patients, presenting with normal mucosa (NM = 53), chronic gastritis (CG = 94), and gastric cancer (GC = 82), by ELISA.

Results: Moderate levels of TNF-α were detected in the NM group (19.9 ± 19.5 pg/ml), which were nearly doubled in patients with CG (35.7 ± 28.0 pg/ml) and drastically declined in GC patients (1.8 ± 5.9 pg/ml). The serum levels of IL-8, however, were not statistically different amongst these three groups.

Conclusion: TNF-α serum concentration seemed to undergo up- and downregulation, when moving from NM to CG and from CG to GC, respectively. If confirmed in a prospective study, this cytokine can behave as a serum indicator of gastric inflammation and malignant transformation.

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血清肿瘤坏死因子α水平的改变与胃癌的组织病理进展有关

背景:炎性细胞因子如肿瘤坏死-α (TNF-α)和IL-8在胃癌发生中的作用已被研究，但其影响仍有待进一步阐明。方法:采用ELISA法检测粘膜正常(NM = 53)、慢性胃炎(CG = 94)、胃癌(GC = 82)的消化不良患者血清中这些细胞因子的浓度及幽门螺杆菌的血清状态。结果:NM组中TNF-α水平为19.9±19.5 pg/ml，而CG组中TNF-α水平为35.7±28.0 pg/ml，几乎翻倍，GC组中TNF-α水平急剧下降(1.8±5.9 pg/ml)。血清IL-8水平在三组间无统计学差异。结论:TNF-α血清浓度在从NM向CG和从CG向GC移动时分别出现上调和下调。如果在前瞻性研究中得到证实，该细胞因子可以作为胃炎症和恶性转化的血清指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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