Seroreversion to Chlamydia trachomatis Pgp3 antigen among children in a hyperendemic region of Amhara, Ethiopia.

Christine Tedijanto, Solomon Aragie, Sarah Gwyn, Dionna M Wittberg, Taye Zeru, Zerihun Tadesse, Ambahun Chernet, Isabel J B Thompson, Scott D Nash, Thomas M Lietman, Diana L Martin, Jeremy D Keenan, Benjamin F Arnold
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Abstract

Monitoring trachoma transmission with antibody data requires characterization of decay in IgG to Chlamydia trachomatis antigens. In a three-year longitudinal cohort in a high transmission setting, we estimated a median IgG half-life of 3 years and a seroreversion rate of 2.5 (95% CI: 1.6, 3.5) per 100 person-years.

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埃塞俄比亚阿姆哈拉高流行区幼儿沙眼衣原体Pgp3抗原的血清逆转。
用抗体数据监测沙眼传播需要表征沙眼衣原体抗原IgG的衰变。在一个高传播环境中的三年纵向队列中,我们估计IgG的中位半衰期为3年,血清逆转率为每100人年2.5(95%CI:1.6,3.8)。
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