Translating Imaging Nanoprobes Design to the Clinic

IF 3.4 Q2 CHEMISTRY, ANALYTICAL Analysis & sensing Pub Date : 2023-07-10 DOI:10.1002/anse.202300038
Wenbo Sun, Geng Tian, Prof. Dr. Lehui Lu
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Abstract

The use of nanoprobes has revolutionized the way we approach medical diagnosis and treatment. These tiny particles are designed to target specific cells or tissues within the body, allowing doctors to visualize and monitor disease progression in real-time. The paramount consideration in the utilization of nanoprobes is their safety. Unlike traditional contrast agents, which can cause adverse reactions in some patients, these probes are specifically engineered to minimize any potential harm. And it can promote the rapid development of new biological imaging techniques in various fields such as biological structure and functional imaging, disease diagnosis, in situ imaging, and real-time dynamic imaging at the in vivo level. Based on the principles and mechanisms of imaging, this study focuses on the recent applications of nanoprobes for several typical imaging techniques (magnetic resonance imaging, computed tomography imaging, fluorescence imaging, and acoustic imaging) with the aim of providing researchers with a fresh perspective on precise disease diagnosis and treatment through the development of nanoprobes.

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将成像纳米探针设计应用于临床
纳米探针的使用彻底改变了我们进行医学诊断和治疗的方式。这些微小的颗粒被设计成针对体内特定的细胞或组织,使医生能够实时观察和监测疾病的进展。纳米探针的安全性是其应用的首要考虑因素。传统的造影剂会对一些患者造成不良反应,与之不同的是,这些探针是专门设计的,可以将任何潜在的危害降到最低。它可以促进生物结构与功能成像、疾病诊断、原位成像、活体水平实时动态成像等各个领域的生物成像新技术的快速发展。本文从成像的原理和机制出发,重点介绍了纳米探针在几种典型成像技术(磁共振成像、计算机断层成像、荧光成像和声学成像)中的最新应用,旨在通过纳米探针的发展为疾病的精确诊断和治疗提供新的视角。
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