{"title":"Solid-Phase Synthesis : A Practical Guide","authors":"S. Kates, F. Albericio","doi":"10.1201/9781482270303","DOIUrl":null,"url":null,"abstract":"The solid support strategy in solid-phase synthesis amino acids -alpha-amino protecting groups side-chain protecting groups solid supports for the synthesis of peptides and small molecules coupling methods - solid-phase formation of amide and ester bonds homodetic cyclic peptides disulfide formation in synthetic peptides and proteins -the state of the art solid-phase convergent approaches to the synthesis of native peptides and proteins preparation of glyco-, phospho-, and sulfopeptides oligonucleotide synthesis synthesis of oligonucleotide-peptide conjugates and nucleopeptides the chemistry of peptide nucleic acids solid-phase synthesis of pseudopeptides and oligomeric peptide backbone mimetics instrumentation the purification of synthetic peptides analysis of synthetic peptides the chromatographic analysis of combinational arrays - parallel HPLC and HPLC-MS.","PeriodicalId":0,"journal":{"name":"","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2000-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"198","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1201/9781482270303","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 198
Abstract
The solid support strategy in solid-phase synthesis amino acids -alpha-amino protecting groups side-chain protecting groups solid supports for the synthesis of peptides and small molecules coupling methods - solid-phase formation of amide and ester bonds homodetic cyclic peptides disulfide formation in synthetic peptides and proteins -the state of the art solid-phase convergent approaches to the synthesis of native peptides and proteins preparation of glyco-, phospho-, and sulfopeptides oligonucleotide synthesis synthesis of oligonucleotide-peptide conjugates and nucleopeptides the chemistry of peptide nucleic acids solid-phase synthesis of pseudopeptides and oligomeric peptide backbone mimetics instrumentation the purification of synthetic peptides analysis of synthetic peptides the chromatographic analysis of combinational arrays - parallel HPLC and HPLC-MS.