Dystonic reactions following neuroleptics: time course and proposed mechanisms.

D L Garver, D M Davis, H Dekirmenjian, S Ericksen, L Gosenfeld, J Haraszti
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引用次数: 24

Abstract

The occurrence of acute dystonic reactions was studied relative to drug pharmacokinetic parameters following a single dose of the phenothiazine, butaperazine. Dystonias occurred more than one half-life from peak butaperazine levels, 23 to 56 h after drug administration. The authors postulate that the appearance of dystonias on falling plasma concentrations may be due to disruption of dopaminergic-cholinergic balance caused by differential antidopaminergic and anticholinergic potencies of the drug.

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抗精神病药后的张力障碍反应:时间过程和可能的机制。
急性肌张力障碍反应的发生研究相对于药物的药代动力学参数后,单剂量的吩噻嗪,丁哌嗪。肌张力障碍发生在丁哌嗪峰值后的一个半衰期,服药后23至56小时。作者推测,血浆浓度下降时肌张力障碍的出现可能是由于药物的不同抗多巴胺能和抗胆碱能效力引起的多巴胺能-胆碱能平衡的破坏。
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Biochemical background for clinical drug effect Long term effects of psychotropic drugs Social implications of psychopharmacology Straiatum and neuroleptics Biochemical findings in mental illness. Affective disorders
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