Control of prolactin secretion by the hypothalamic catecholamines.

Advances in sex hormone research Pub Date : 1976-01-01
R M MacLeod, I Login
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Abstract

The neuroendocrine control of prolactin secretion is very complex. Even though the hypothalamus exerts a profound inhibitory influence upon the secretion of this hormone, the mechanism(s) involved is poorly understood. The cerebrospinal fluid seems to be becoming increasingly important as regards neuroendocrine regulatory mechanisms involving prolactin. Pharmacological agents such as apomorphine and many of the ergot alkaloids are very effective inhibitors of the secretion of prolactin. Still other pharmacological agents such as DMPEA, alpha-methyldopa, reserpine, and certain of the phenothiazines are very effective in causing a stimulation of prolactin secretion.

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下丘脑儿茶酚胺控制催乳素分泌。
神经内分泌对催乳素分泌的控制是非常复杂的。尽管下丘脑对这种激素的分泌具有深远的抑制作用,但其机制尚不清楚。在涉及催乳素的神经内分泌调节机制方面,脑脊液似乎变得越来越重要。药物制剂,如阿波啡和许多麦角生物碱是非常有效的抑制剂分泌催乳素。还有其他药物如DMPEA, α -甲基多巴,利血平和某些吩噻嗪类药物在刺激催乳素分泌方面非常有效。
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