[Effect of carbonic acid concentration in blood on content of keto-acids and redox state of nicotinamide coenzymes in rabbit tissues].

Ukrains'kyi biokhimichnyi zhurnal Pub Date : 1977-09-01
D O Mel'nychuk, L V Skoryk, C Scholz, E V Mitsyk, M F Guly
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Abstract

A rise in the level of carbonic acid in animal blood at practically unchanged pH causes an increase in the value of free [NAD+]/[NADH] and [NADP+]/[NADPH] ratios in the liver cells cytoplasm. The increase in the oxidizing power of the liver cells cytoplasm is observed against a background of a rise in both the total level of keto-acids in blood and concentration of pyruvate oxaloacetate and alpha-ketoglutarate in the liver and kidneys of animals. The level of lactate, glutamate and citrate in these tissues also grows. The level of ketonic bodies in blood of the animals with a higher concentration of carbonic acid is somewhat lower than that in the animals with a lower concentration of HCO3 and CO2 in blood.

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[血中碳酸浓度对兔组织中酮酸含量及烟酰胺辅酶氧化还原状态的影响]。
在pH值几乎不变的情况下,动物血液中碳酸水平的上升会导致肝细胞细胞质中游离[NAD+]/[NADH]和[NADP+]/[NADPH]比值的增加。肝细胞细胞质氧化能力的增加是在动物血液中酮酸总水平和肝脏和肾脏中丙酮酸草酰乙酸酯和α -酮戊二酸浓度升高的背景下观察到的。这些组织中乳酸盐、谷氨酸盐和柠檬酸盐的含量也会增加。碳酸浓度较高的动物血液中的酮体水平略低于血液中HCO3和CO2浓度较低的动物。
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