The effect of interruption of the short posterior ciliary arteries on slow axoplasmic transport and histology within the optic nerve of the rhesus monkey.

Investigative ophthalmology Pub Date : 1976-06-01
N S Levy
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Abstract

Tritiated leucine was injected into the vitreous of rhesus monkey eyes to make it available for protein synthesis by the ganglion cells. The short posterior ciliary arteries were cut three hours later or several weeks prior to the leucine injection. A reduction of labeled protein within the retrolaminar optic nerve was seen in all eyes so treated. Autoradiography revealed a diffuse reduction of axoplasmic transport into these optic nerve heads. There was consistent evidence of focal obstruction of labeled protein at the interface between the lamina scleralis and retrolaminar optic nerve. Vacuoles appeared in the most severely affected areas. These histologic changes were followed by gliosis in the areas of ischemic damage. Glaucomatous cupping of the optic nerve head was not seen within six weeks following the induced ischemia.

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阻断短后睫状动脉对恒河猴视神经内慢轴浆运输和组织学的影响。
将氚化亮氨酸注射到恒河猴眼睛的玻璃体中,使其可用于神经节细胞合成蛋白质。在注射亮氨酸前3小时或数周切断短的纤毛后动脉。在所有接受治疗的眼睛中,层后视神经内标记蛋白减少。放射自显像显示弥漫性轴浆转运到视神经头的减少。有一致的证据表明,标记蛋白在巩膜板和视神经板后界面处有局灶性阻塞。液泡出现在最严重的部位。这些组织学变化之后是缺血损伤区域的胶质瘤。青光眼视神经头拔火罐在诱导缺血后6周内未见。
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A new technique for the vital staining of the corneal endothelium. Niemann-Pick disease-like inclusions caused by a hypocholesteremic agent. Experimental disciform edema and necrotizing keratitis in the rabbit. Immunofluorescent studies on the trabecular meshwork in open-angle glaucoma. A randomized technique of constant-pressure infusion.
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