Antiandrogens.

Advances in sex hormone research Pub Date : 1976-01-01
R O Neri
{"title":"Antiandrogens.","authors":"R O Neri","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Many antiandrogens, mainly steroidal and some nonsteroidal agents, have been synthesized and tested in several available biological assays. Unfortunately, many of these compounds have other biological activities which make it difficult to ascertain the precise mechanism of antiandrogenic action. The blocking of androgen action can be accomplished by a number of ways: (1) the inhibition of gonadotropin release and/or synthesis, (2) the interference with testosterone and/or dihydrotestosterone biosynthesis, (3) the blocking of protein synthesis, and (4) the competition with androgens at receptor sites. Although the major reason for the development of antiandrogens is to utilize them in certain clinical situations, some have become important tools in studying androgen action, particularly on the molecular level. The clinical effectiveness of some antiandrogens in prostatic hyperplasias, hirsutism, and acne represents an important advance in therapeutics, but the search for more potent antiandrogens with minimal side effects should continue.</p>","PeriodicalId":75452,"journal":{"name":"Advances in sex hormone research","volume":"2 ","pages":"233-62"},"PeriodicalIF":0.0000,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in sex hormone research","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Many antiandrogens, mainly steroidal and some nonsteroidal agents, have been synthesized and tested in several available biological assays. Unfortunately, many of these compounds have other biological activities which make it difficult to ascertain the precise mechanism of antiandrogenic action. The blocking of androgen action can be accomplished by a number of ways: (1) the inhibition of gonadotropin release and/or synthesis, (2) the interference with testosterone and/or dihydrotestosterone biosynthesis, (3) the blocking of protein synthesis, and (4) the competition with androgens at receptor sites. Although the major reason for the development of antiandrogens is to utilize them in certain clinical situations, some have become important tools in studying androgen action, particularly on the molecular level. The clinical effectiveness of some antiandrogens in prostatic hyperplasias, hirsutism, and acne represents an important advance in therapeutics, but the search for more potent antiandrogens with minimal side effects should continue.

分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
抗雄激素。
许多抗雄激素,主要是甾体和一些非甾体药物,已经合成并在几种可用的生物分析中进行了测试。不幸的是,许多这些化合物具有其他生物活性,这使得很难确定抗雄激素作用的确切机制。雄激素作用的阻断可以通过以下几种方式实现:(1)抑制促性腺激素的释放和/或合成,(2)干扰睾酮和/或双氢睾酮的生物合成,(3)阻断蛋白质合成,(4)在受体位点与雄激素竞争。虽然开发抗雄激素的主要原因是为了在某些临床情况下利用它们,但一些抗雄激素已成为研究雄激素作用的重要工具,特别是在分子水平上。一些抗雄激素治疗前列腺增生、多毛症和痤疮的临床疗效代表了治疗学的重要进展,但寻找副作用最小的更有效的抗雄激素应继续进行。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Guinea pig seminal vesicle epithelium: a model for androgen action. Roles of age and androgen in the regulation of sex accessory organs. Effects of narcotics on the reproductive system. Influence of the adrenal gland on gonadal function. Estrogen biosynthesis in the ovaries and testes.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1