{"title":"[delta-9-Tetrahydrocannabinol (THC) inhibition of the membrane transport system for thymidine].","authors":"B Desoize, C Léger, G Nahas","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>THC decreases 3H-thymidine uptake within 15 sec. after addition of the drug to the culture (L1210 murine lymphoma cells and human lymphocytes). Experiments performed at 0 degrees C indicate that THC has no action on thymidine binding to the carrier. THC in micromolar concentration inhibits DNA synthesis through a alteration of membrane configuration.</p>","PeriodicalId":10544,"journal":{"name":"Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles","volume":"287 16","pages":"1441-4"},"PeriodicalIF":0.0000,"publicationDate":"1978-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
THC decreases 3H-thymidine uptake within 15 sec. after addition of the drug to the culture (L1210 murine lymphoma cells and human lymphocytes). Experiments performed at 0 degrees C indicate that THC has no action on thymidine binding to the carrier. THC in micromolar concentration inhibits DNA synthesis through a alteration of membrane configuration.
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