Cutaneous hydroxystereoid dehydrogenases and rat-hair cycle.

Archiv fur dermatologische Forschung Pub Date : 1975-01-01
F Crovato, R Bertamino, G Moretti
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Abstract

The histochemical activity pattern of a number of hydroxysteroid dehydrogenases was studied during a provoked hair cycle in the rat skin. The intensity of reaction was high with dehydroepiandrosterone, estradiol, androsterone and pregnenolone, and none with 11-beta-hydroxyprogesterone, testosterone, dihydrotestosterone, 17-alpha-hydroxypregnenolone and 17-alpha-hydroxyprogesterone. Reactivity also varied with the hair cycle. The reactive sit-s were the acini of sebaceous glands and the hair sheaths.

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皮肤羟基类固醇脱氢酶与鼠毛循环。
研究了大鼠皮肤毛发周期中若干羟基类固醇脱氢酶的组织化学活性模式。脱氢表雄酮、雌二醇、雄酮和孕烯醇酮反应强度高,11- β -羟孕酮、睾酮、二氢睾酮、17- α -羟孕烯醇酮和17- α -羟孕酮反应强度低。反应性也随着头发周期的变化而变化。活性因子为皮脂腺腺泡和毛鞘。
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