Visuospatial Working Memory Deficits in Patient with Schizophrenia

K. Bala, S. Sarkhel, M. Jahan, A. Bakhla
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Abstract

Background: Review of Literature suggests that cognitive deficits of patients with schizophrenia can be attributed to an inherent deficit of working memory. Hence, present study was conducted to assess the spatial working memory in schizophrenic patients, to compare it with normal control and to find out clinical and sociodemographic correlates of spatial working memory deficit. Material & Method: The sample consisted of 25 schizophrenic patients (diagnosed according to DCR of ICD-10) and 25 normal participants. Psychopathology was rated on Brief Psychiatric Rating Scale. Normal participants were screened using General Health Questionnaire-12. The Rey–Osterrieth Complex Figure Test was used to assess visuo-spatial working memory. Result: Result shows that schizophrenic patient performed poorly on all the trials of ROCFT than normal control. Increased severity of psychopathology was correlated with poor visuo-spatial working memory. Conclusion: Since severity of psychopathology was correlated with poor immediate recall trial and delayed recall trial, longitudinal studies will be important to know whether these deficits improve with improvement in psychopathology. Findings will help in framing cognitive rehabilitation strategies for management of the schizophrenic patients.
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精神分裂症患者的视觉空间工作记忆缺陷
背景:文献综述表明,精神分裂症患者的认知缺陷可归因于固有的工作记忆缺陷。因此,本研究旨在评估精神分裂症患者的空间工作记忆,并将其与正常对照进行比较,以找出空间工作记忆缺陷的临床和社会人口学相关因素。材料与方法:样本包括25例精神分裂症患者(根据ICD-10的DCR诊断)和25例正常人。采用简易精神病学评定量表评定精神病理。使用一般健康问卷-12对正常参与者进行筛选。采用Rey-Osterrieth复杂图形测验评估视觉空间工作记忆。结果:精神分裂症患者在ROCFT各项试验中的表现均低于正常对照组。精神病理加重与视觉空间工作记忆不良相关。结论:由于精神病理严重程度与不良的即时回忆试验和延迟回忆试验相关,因此纵向研究对于了解这些缺陷是否随着精神病理的改善而改善具有重要意义。研究结果将有助于制定精神分裂症患者管理的认知康复策略。
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