[Relation between catecholamines metabolism and CoA content in rat tissues].

Abstract

The content of CoA in the liver, heart, kidneys and brain of rats was studied as affected by ACTH, melipramine and prednisolone. After ACTH administration the content of CoA in the liver increases. When blocking "capture" and "reverse capture" of catecholamines by melipramine the content of CoA in the kidneys lowers. Administration of melipramines causes no changes in the content of CoA in the tissues. Under the effect of prednisolone there is a tendency to the CoA content decrease in the kidneys. In the other tissues the subcutaneous administration of the preparations does not effect the content of CoA. Possible mechanism of the studied pharmacologic substances effect on the content of CoA in the tissues is under discussion.