Characteristic chromosome markers and regularity of karyotype changes of continuous hematopoietic cell lines established from monkeys with malignant lymphoma. — Report IV

Experimentelle Pathologie Pub Date : 1979-01-01 DOI:10.1016/S0014-4908(79)80034-4

D.S. Markaryan, I.A. Gvaramija, V.Z. Agrba, V.A. Vasiljeva, I.A. Sangulija, V.V. Timanovskaja

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Abstract

The dynamic karyotype studies of SU-1, SU-2, KMMA-2 (produce C-type oncorna virus) lines and KMPG-1, SPG-2 and SPG-3 (produce HYP) lines have been carried out. The lines have been established from hematopoietic cells of Macaca arctoides and Papio hamadryas monkeys with malignant lymphomas.

Some lines had peridiploid-pseudodiploid karyotype and the other ones were aneuploid. Selectivity of structural and numerical disturbances of chromosomes 1, 9, 10, 12, 13, 15, 17, 18, 20 has been revealed, which points out to a certain specificity of the karyotype changes in malignization and transformation. The number of chromosomes more or less being differentiated in aneuploidization was subjected to more changeability as compared with chromosomes being well differentiated. It has not yet been possible to observe some kind of parallelism between the character of karyotype changes and the virus being produced (C-type or HVP).

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猴恶性淋巴瘤连续造血细胞系染色体特征标记及核型变化规律。-报告四

对产c型癌病毒的SU-1、SU-2、kma -2系和产HYP的KMPG-1、SPG-2、SPG-3系进行了动态核型研究。这些细胞系是从患有恶性淋巴瘤的猕猴和猕猴的造血细胞中建立的。部分系为周二倍体-伪二倍体核型，其余系为非整倍体。揭示了1、9、10、12、13、15、17、18、20号染色体的结构和数量干扰的选择性，这表明在恶性化和转化过程中核型变化具有一定的特异性。与分化良好的染色体相比，非整倍化中分化程度较高或较低的染色体数量具有更大的可变性。目前还不可能观察到核型变化的特征与产生的病毒(c型或HVP)之间的某种相似性。

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