Correlation of various cardiac markers in diagnosed case of acute MI

Abstract

Introduction: The ischemic injury to the heart and its extent of damage is directly associate with the length of ischemia. For the post mortem diagnosis of MI during an autopsy poses a challenge, particularly in cases of very minute myocardial infract. Biochemical markers provide a very useful tool for the assessment of acute coronary syndrome. These are total creatinine kinase, the MB isoforms and myoglobin,as well as the troponin I(cTnI) and cardiac troponin T (cTnT). The aim of the present study was to study status of cardiac markers like CPK-MB, LDH, Trop-I in diagnosed case of acute MI. Material and Methods: In this prospective study, 35 cases of sudden death that were studied at tertiary care government hospital attached to post-mortem centre during the period from April 2017 to July2018 for the underlying pathology for the sudden death by the assessment of various biochemical markers. Results: It was observed that out of 35 cases, CPK-MB levels were elevated in 29 cases. LDH levels were raised only in 4 cases. Troponin-I levels were raised in 33 cases. Of all the enzymes Troponin-I levels were raised in 94% cases as compared to the other two. It was observed that the sensitivity and specific for CPK-MB, LDH and Trop I were 84% and 30%, 72% and 20 %, 92% and 74% respectively. Conclusion: It was concluded that for the diagnosis of myocardial infarction it is important to perform serial measurement of cTnI because the first measurement may still be negative when the case presents early after the onset of symptoms. © 2020 Published by Innovative Publication. This is an open access article under the CC BY-NC license (https://creativecommons.org/licenses/by-nc/4.0/)