Gerontologic public health problem of obesity in early old age

Abstract

T present study investigated the effects of M. charantia on haematological changes of streptozotocin-induced diabetic Wistar rats. Forty healthy adult Wistar rats of both sexes were randomly assigned into five groups A, B, C, D and E of eight rats each. Group A were the control (normal rats); B were the experimentally-induced diabetic rats; C were diabetic rats treated with methanolic extracts of M. charantia for two weeks (withdrawal group); D were diabetic rats treated with methanolic extracts of M. charantia for four weeks. E was diabetic rats treated glimepiride for four weeks. Blood samples obtained by cardiac puncture were used for haematological studies. Results showed significant (p<0.05) increase in most RBC indices in groups D and E. Reduced WBC and NEUT count in diabetic group was significantly (p<0.05) increased in groups D and E. Lymphocyte count was not significantly affected. Platelet count, PDW and MPV were significantly (p<0.05) reduced in groups D and E following an increase in diabetic group. Thus M. charantia could restore some haematological changes in diabetic animals, and in a manner similar to glimepiride.