{"title":"Significance of the multifunctional protein C system research in the treatment of patients with indirect anticoagulants (literature review)","authors":"V. Egorova, A. A. Zvyagin, V. Demidova","doi":"10.25199/2408-9613-2022-9-1-12-18","DOIUrl":null,"url":null,"abstract":"The multifunctional protein C system regulates both hemostasis and the immune system in response to vascular and inflammatory damage, inhibits thrombinogenesis at an early stage of clotting. A decrease in protein C levels in clinical practice may be associated with vitamin K deficiency, as well as with coumarin therapy. Prolonged use of indirect anticoagulants may be accompanied by a decrease in protein C levels and contribute to the development of rebound thrombosis and thromboembolism. The depth of violations of the protein C system indicates the activation of the microthrombosis process and may affect the outcome of treatment of surgical patients.","PeriodicalId":366300,"journal":{"name":"Wounds and wound infections. The prof. B.M. Kostyuchenok journal","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Wounds and wound infections. The prof. B.M. Kostyuchenok journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.25199/2408-9613-2022-9-1-12-18","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The multifunctional protein C system regulates both hemostasis and the immune system in response to vascular and inflammatory damage, inhibits thrombinogenesis at an early stage of clotting. A decrease in protein C levels in clinical practice may be associated with vitamin K deficiency, as well as with coumarin therapy. Prolonged use of indirect anticoagulants may be accompanied by a decrease in protein C levels and contribute to the development of rebound thrombosis and thromboembolism. The depth of violations of the protein C system indicates the activation of the microthrombosis process and may affect the outcome of treatment of surgical patients.