Controlling Electrospinning Jet Using Microscopic Model for Ideal Tissue Engineering Scaffolds

S. Maghsoodlou, S. Poreskandar
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Abstract

Electrospinning has recently emerged as a widespread technology to produce synthetic nanofibrous and the best candidates for many important applications like scaffolds in tissue engineering. Creating porosity is the primary challenge of tissue engineering scaffolds. But, the most important challenge is to create uniform nanofibers. For these reasons, controlling producing of electrospun nanofiber becomes important. The most suitable method for controlling instability is using modeling and computer simulations. The dynamic analysis of the jet formation and its instability is difficult during the process. In this study, the behavior of the electrospinning process has been investigated by using bead-spring model to see the process in detail. Simulation of this model showed the jet behavior from the first second to the end by bringing in one bead step by step. Therefore, by increasing the number of beads, the behavior of jet during whipping part was obviously expressed.
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理想组织工程支架微观模型控制静电纺丝射流
静电纺丝是近年来广泛应用于合成纳米纤维的技术,也是组织工程中支架等许多重要应用的最佳候选材料。制造孔隙是组织工程支架的主要挑战。但是,最重要的挑战是制造均匀的纳米纤维。因此,控制静电纺纳米纤维的生产变得十分重要。控制不稳定性最合适的方法是利用建模和计算机模拟。在此过程中,射流形成及其不稳定性的动力学分析是一个难点。本文采用串珠-弹簧模型对静电纺丝过程进行了详细的研究。通过对该模型的仿真,模拟了从第一秒到最后一步一步引入一个头的射流行为。因此,通过增加微珠的数量,可以明显地表达射流在鞭打部分的行为。
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