ASSESSMENT OF THE AUTOPHAGY PROCESS IN MEN OF DIFFERENT BODY WEIGHT IN DIFFERENT AGE PERIODS

Abstract

The study group consisted of 20 men of various ages (14-69 years) and weight. To assess the processes of autophagy, the activity of the protein Beclin-1 was used. In individuals with normal body weight, the presence of positive reliable correlations between the level of beclin-1 and extracellular water was revealed (r = 0.96; p <0.01). In the obese group, there was a significant positive relationship between beclin-1 and the amount of triglycerides (r = 0,57; p <0,05); muscle mass (r = 0,62; p <0,05); lean mass (r = 0,62; p <0,05); common liquid (r = 0,62; p <0,05). In old age, there was a direct correlation between the level of beclin-1 and intracellular fluid (r = 0,84; p <0,05). In men, autophagy was less dependent on age, and to a greater extent on the content of extracellular water in persons with normal weight and muscle mass and total water content in persons with obesity.