{"title":"Pathological Techniques in Toxicology","authors":"P. Greaves","doi":"10.1002/9780470744307.GAT039","DOIUrl":null,"url":null,"abstract":"Histopathological evaluation remains an important part of the assessment of the adverse effects of xenobiotics on the whole organism. In addition to conventional special staining techniques and electron microscopy, new techniques involving immunocytochemistry, molecular biology and novel visualization procedures have provided additional objective techniques that have enabled better functional and morphological characterization of induced alterations in organs of the body. This chapter covers both conventional and new methods involved in the microscopical assessment of tissue changes induced by xenobiotics. \n \n \nKeywords: \n \nnecropsy; \norgans; \ntissues; \nfixation; \nhistotechnology; \nhistological stains; \nhistochemistry; \nimmunohistochemistry; \nlight microscopic techniques; \nelectron microscopy; \nmorphometry; \nmolecular techniques","PeriodicalId":325382,"journal":{"name":"General, Applied and Systems Toxicology","volume":"46 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2009-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"General, Applied and Systems Toxicology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/9780470744307.GAT039","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Histopathological evaluation remains an important part of the assessment of the adverse effects of xenobiotics on the whole organism. In addition to conventional special staining techniques and electron microscopy, new techniques involving immunocytochemistry, molecular biology and novel visualization procedures have provided additional objective techniques that have enabled better functional and morphological characterization of induced alterations in organs of the body. This chapter covers both conventional and new methods involved in the microscopical assessment of tissue changes induced by xenobiotics.
Keywords:
necropsy;
organs;
tissues;
fixation;
histotechnology;
histological stains;
histochemistry;
immunohistochemistry;
light microscopic techniques;
electron microscopy;
morphometry;
molecular techniques
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