{"title":"Prolongation of Longitudinal Relaxometry Characteristics in Healthy Aging: a Whole Brain MRI Study","authors":"Hayriye Aktaş Dinçer, D. Gökçay","doi":"10.1109/TIPTEKNO50054.2020.9299314","DOIUrl":null,"url":null,"abstract":"Conventional MRI studies have reported several structural changes such as brain atrophy and ventricular enlargement in healthy aging. Quantitative MRI (qMRI) allows the measurement of tissue characteristics such as the longitudinal relaxation times (T1) which provides unique and complementary information to widely used measures of brain signal characteristics. In this study, the T1 values on entire brain were mapped with an ROI based method. T1 prolongation with aging was demonstrated on numerous cortical and subcortical areas such as caudate, thalamus and prefrontal cortex. This outcome was interpreted as increased demyelination in these structures.","PeriodicalId":426945,"journal":{"name":"2020 Medical Technologies Congress (TIPTEKNO)","volume":"36 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2020-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"2020 Medical Technologies Congress (TIPTEKNO)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/TIPTEKNO50054.2020.9299314","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Conventional MRI studies have reported several structural changes such as brain atrophy and ventricular enlargement in healthy aging. Quantitative MRI (qMRI) allows the measurement of tissue characteristics such as the longitudinal relaxation times (T1) which provides unique and complementary information to widely used measures of brain signal characteristics. In this study, the T1 values on entire brain were mapped with an ROI based method. T1 prolongation with aging was demonstrated on numerous cortical and subcortical areas such as caudate, thalamus and prefrontal cortex. This outcome was interpreted as increased demyelination in these structures.
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