Protective Effect of Nigella Sativa Oil on Stress Gastric Ulcer in Hypothyroidal Rats

The Internet Journal of Nutrition and Wellness Pub Date : 2008-12-31 DOI:10.5580/107b

K. Abdel-Sater

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引用次数: 2

Abstract

OBJECTIVE: The aim of this study was to assess the effects of hypothyroidism on the development of acute cold restraint stress gastritis in rats and protective effect of Nigella sativa at the beginning of the acute cold restraint stress. METHODS: 60 rats were randomly divided into six groups; the control (groups I), surgically thyroidectomized group (group II), acute cold restraint stressed group (group III), surgically thyroidectomized plus stressed group (group IV), Nigella sativa oil group (group V) and surgically thyroidectomized plus stressed plus Nigella sativa oil group (group VI). Volume of gastric juice, number and size of ulcer, gastric malonaldehyde, gastric glutathione, gastric protein and serum thyroxine (T4) were measured. RESULTS: Significant increases both of number of gastric ulcer and malonaldehyde while decreases both of glutathione and protein levels in rats in groups III and IV in comparison with control group. While, insignificant increase were observed between control and both of groups II and VI. CONCLUSION: In rats, low thyroid hormone level increase stress gastritis, and this effect can be decreased by treatment with Nigella sativa.

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黑草油对甲状腺功能减退大鼠应激性胃溃疡的保护作用

目的:探讨甲状腺功能减退对大鼠急性冷约束应激性胃炎发生的影响及黑草在急性冷约束应激初期的保护作用。方法:将60只大鼠随机分为6组;对照组(I组)、手术去甲状腺组(II组)、急性冷约束应激组(III组)、手术去甲状腺加应激组(IV组)、黑草油组(V组)、手术去甲状腺加应激加黑草油组(VI组)测定胃液量、溃疡数量和大小、胃丙二醛、胃谷胱甘肽、胃蛋白和血清甲状腺素(T4)。结果:与对照组相比，ⅲ组和ⅳ组大鼠胃溃疡数量和丙二醛均显著增加，谷胱甘肽和蛋白水平均显著降低。结论:低甲状腺激素水平可使大鼠应激性胃炎加重，黑草可减轻应激性胃炎的影响。

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The Internet Journal of Nutrition and Wellness

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