Analysis of a HBV infection model with ALT

Abstract

Mathematical models have been used to understand the factors that govern infectious disease progression in viral infections. Many hepatitis B virus (HBV) models were set up based on the basic virus infection model (BVIM) introduced by Zeuzem et al. and Nowak et al. But some references have pointed out that the basic infection reproductive number of the BVIM is biologically questionable and given the modified models. And so far, no immune model with alanine aminotransferase (ALT) was given based on the modified models. In this paper one immune models with ALT based on the modified model is discussed. The stability analysis and simulation of the model is also given based on clinical data of ALT and HBV DNA.