Some nuclear receptors as application points for drugs with hepatotropic activity

V. Ponamarev
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Abstract

At present, one of the most promising directions in the search for chemical compounds-candidates for drugs is the fundamental study of signaling molecules, whose main function is to transmit information to the cell through ion channels and nuclear receptors associated with G-protein or with enzymatic activity. One of the fundamental tasks of modern pharmacology - the expansion of the range of hepatotropic drugs with a fundamentally new mechanism of action - is currently being actively solved, including through specific chemical compounds that act on cell nuclear receptors, one of which is obeticholic acid.
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一些核受体作为促肝药物的应用点
目前,寻找药物候选化合物最有希望的方向之一是对信号分子的基础研究,其主要功能是通过与g蛋白或酶活性相关的离子通道和核受体向细胞传递信息。现代药理学的基本任务之一——扩大具有全新作用机制的促肝药物的范围——目前正在积极解决,包括通过作用于细胞核受体的特定化合物,其中之一是奥贝胆酸。
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