Population Dynamics of Biosensors for Nano-therapeutic Applications in Internet of Bio-Nano Things

Abstract

The development of nanomedical systems through the Internet of Bio-Nano Things (IoBNT) paradigm promotes designing of therapeutic models to facilitate drug transport and delivery. Such systems utilize microbial communities such as bacteria, which act as biosensors for molecular communication. We model the drug transport and delivery system by considering more realistic properties and characteristics of the biosensor community. We devise a Markov Decision Process (MDP) to model the biosensor lifecycle while considering division and death as parameters to regulate the model. This aids in estimating the required number of drug encapsulated biosensors. The proposed model indicates an increase in the number of instances of biosensor-target interactions that would be required for a better understanding of system dynamics. The proposed approach suggests a populace-aware coordination scheme with 3.5% increase in population, along with 20 -50% increase in information delivery. The solution proposed here can be harnessed in designing the number of optimum drug dosages. We show the effectiveness of our model with 90% increase in average biosensor lifetime, while highlighting the increase in the energy utilized in the network.