The role of prostaglandins in the pathogenesis of hypertension.

Clinical science and molecular medicine. Supplement Pub Date : 1978-12-01 DOI:10.1042/cs055207s
C M Markov
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引用次数: 6

Abstract

1. Biosynthesis of PGE2 from [14C]arachidonic acid has been found to be lower and PGF2alpha higher in the renal medulla of spontaneously hypertensive (SH) rats than in normal Wistar (NW) rats. 2. Biosynthesis of prostacyclin (PGF1alpha) from [14C]arachidonic acid was decreased in lungs, aorta and heart of SH rats. 3. Metabolism of [3H]PGF1alpha was decreased in renal cortex and lungs and PGE2 increased in SH rats in comparison with NW rats. Thus the lungs of SH rats let more PGF and less PGE enter the systemic circulation. 4. Emotional stress decreased the metabolism of [3H]PGF1alpha in lungs of SH and NW rats, the effect being less in SH rats.

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前列腺素在高血压发病中的作用。
1. 与正常Wistar (NW)大鼠相比，自发性高血压(SH)大鼠肾髓质中[14C]花生四烯酸的PGE2生物合成较低，pgf2 α较高。2. [14C]花生四烯酸在SH大鼠的肺、主动脉和心脏中生物合成前列环素(pgf1 α)减少。3.与NW大鼠相比，SH大鼠肾皮质和肺中[3H] pgf1 α代谢降低，PGE2代谢升高。因此，SH大鼠的肺部让更多的PGF和更少的PGE进入体循环。4. 情绪应激降低SH大鼠和NW大鼠肺[3H] pgf1 α的代谢，但SH大鼠的作用较小。
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Clinical science and molecular medicine. Supplement
Clinical science and molecular medicine. Supplement
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Proceedings of the Fifth Meeting of the International Society of Hypertension, Paris, 12-14 June 1978. Brain catecholamines and catecholamine-synthesizing enzymes in renovascular hypertension in the rat. Enhanced hypothalamic noradrenaline biosynthesis in Goldblatt I renovascular hypertension. Definitive evidence for renin in rat brain by affinity chromatographic separation from protease. Renal release of active and inactive renin in essential and renovascular hypertension.
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